TY - JOUR
T1 - Evolutionary dynamics and adaptive benefits of deleterious mutations in crop gene pools
AU - Dwivedi, Sangam L.
AU - Heslop-Harrison, Pat
AU - Spillane, Charles
AU - McKeown, Peter C.
AU - Edwards, David
AU - Goldman, Irwin
AU - Ortiz, Rodomiro
PY - 2023/6
Y1 - 2023/6
N2 - Mutations with deleterious consequences in nature may be conditionally deleterious in crop plants. That is, while some genetic variants may reduce fitness under wild conditions and be subject to purifying selection, they can be under positive selection in domesticates. Such deleterious alleles can be plant breeding targets, particularly for complex traits. The difficulty of distinguishing favorable from unfavorable variants reduces the power of selection, while favorable trait variation and heterosis may be attributable to deleterious alleles. Here, we review the roles of deleterious mutations in crop breeding and discuss how they can be used as a new avenue for crop improvement with emerging genomic tools, including HapMaps and pangenome analysis, aiding the identification, removal, or exploitation of deleterious mutations.
AB - Mutations with deleterious consequences in nature may be conditionally deleterious in crop plants. That is, while some genetic variants may reduce fitness under wild conditions and be subject to purifying selection, they can be under positive selection in domesticates. Such deleterious alleles can be plant breeding targets, particularly for complex traits. The difficulty of distinguishing favorable from unfavorable variants reduces the power of selection, while favorable trait variation and heterosis may be attributable to deleterious alleles. Here, we review the roles of deleterious mutations in crop breeding and discuss how they can be used as a new avenue for crop improvement with emerging genomic tools, including HapMaps and pangenome analysis, aiding the identification, removal, or exploitation of deleterious mutations.
KW - crop improvement
KW - deleterious variants
KW - genome editing
KW - genomic prediction
KW - HapMaps
KW - mating system
KW - propagation
KW - selective sweeps
KW - wild relatives
UR - http://www.scopus.com/inward/record.url?scp=85147867961&partnerID=8YFLogxK
U2 - 10.1016/j.tplants.2023.01.006
DO - 10.1016/j.tplants.2023.01.006
M3 - Review article
C2 - 36764870
AN - SCOPUS:85147867961
SN - 1360-1385
VL - 28
SP - 685
EP - 697
JO - Trends in Plant Science
JF - Trends in Plant Science
IS - 6
ER -