Evidence of fusion between host and donor myoblasts in skeletal muscle grafts

T. A. Partridge, Miranda Grounds, J. C. Sloper

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

THE skeletal muscle fibre is a long, multinucleated cell formed by fusion of mononuclear precursor cells (myoblasts) with one another1-3 and with muscle cells in various stages of maturity4,5. In subjects suffering from inherited recessive myopathies, muscle function might be restored if normal myoblasts could be made to fuse with defective muscle fibres during muscle growth or regeneration. Such a method of introducing new genetic information into muscle fibres requires that myoblasts can enter a region of growing or regenerating muscle, and that these myoblasts can participate in the formation of new muscle fibres by fusion with locally derived cells. Recently we have shown, using isoenzymes of malate dehydrogenase as markers, that host muscle cell precursors can enter muscle grafts6. Here we present evidence, based on the use of a more sensitive isoenzyme marker, that fusion can occur between host and donor muscle cell precursors.

Original languageEnglish
Pages (from-to)306-308
Number of pages3
JournalNature
Volume273
Issue number5660
DOIs
Publication statusPublished - 1 Dec 1978
Externally publishedYes

Fingerprint

Dive into the research topics of 'Evidence of fusion between host and donor myoblasts in skeletal muscle grafts'. Together they form a unique fingerprint.

Cite this