Projects per year
Abstract
© 2016 American Heart Association, Inc.
Increases in arterial carbon dioxide tension (hypercapnia) elicit potent vasodilation of cerebral arterioles. Recent studies have also reported vasodilation of the internal carotid artery during hypercapnia, but the mechanism(s) mediating this extracranial vasoreactivity are unknown. Hypercapnia increases carotid shear stress, a known stimulus to vasodilation in other conduit arteries. To explore the hypothesis that shear stress contributes to hypercapnic internal carotid dilation in humans, temporal changes in internal and common carotid shear rate and diameter, along with changes in middle cerebral artery velocity, were simultaneously assessed in 18 subjects at rest and during hypercapnia (6% carbon dioxide). Middle cerebral artery velocity increased significantly (69±10-103±17 cm/s; P
Increases in arterial carbon dioxide tension (hypercapnia) elicit potent vasodilation of cerebral arterioles. Recent studies have also reported vasodilation of the internal carotid artery during hypercapnia, but the mechanism(s) mediating this extracranial vasoreactivity are unknown. Hypercapnia increases carotid shear stress, a known stimulus to vasodilation in other conduit arteries. To explore the hypothesis that shear stress contributes to hypercapnic internal carotid dilation in humans, temporal changes in internal and common carotid shear rate and diameter, along with changes in middle cerebral artery velocity, were simultaneously assessed in 18 subjects at rest and during hypercapnia (6% carbon dioxide). Middle cerebral artery velocity increased significantly (69±10-103±17 cm/s; P
Original language | English |
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Pages (from-to) | 1217-1224 |
Number of pages | 8 |
Journal | Hypertension |
Volume | 68 |
Issue number | 5 |
Early online date | 29 Aug 2016 |
DOIs | |
Publication status | Published - 1 Nov 2016 |
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Dive into the research topics of 'Evidence for shear stress-mediated dilation of the internal carotid artery in humans'. Together they form a unique fingerprint.Projects
- 2 Finished
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Healthy Vascular Aging in Humans - Defining the Direct Effects of Exercise on Arterial Adaptation
Green, D. (Investigator 01)
ARC Australian Research Council
1/01/13 → 31/12/16
Project: Research
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Does Manipulation of Arterial Shear Stress Enhance Cerebrovascular Function and Cognition in the Aging Brain
Green, D. (Investigator 01), Lautenschlager, N. (Investigator 02), Cox, K. (Investigator 03), Badcock, J. (Investigator 04) & Pestell, C. (Investigator 05)
NHMRC National Health and Medical Research Council
1/01/13 → 31/12/16
Project: Research