Evidence for shear stress-mediated dilation of the internal carotid artery in humans

Howard H. Carter, Ceri L. Atkinson, Ilkka H. A. Heinonen, Andrew Haynes, Elisa Robey, Kurt J. Smith, P.N. Ainslie, R.L. Hoiland, Daniel J. Green

    Research output: Contribution to journalArticle

    33 Citations (Scopus)
    369 Downloads (Pure)

    Abstract

    © 2016 American Heart Association, Inc.
    Increases in arterial carbon dioxide tension (hypercapnia) elicit potent vasodilation of cerebral arterioles. Recent studies have also reported vasodilation of the internal carotid artery during hypercapnia, but the mechanism(s) mediating this extracranial vasoreactivity are unknown. Hypercapnia increases carotid shear stress, a known stimulus to vasodilation in other conduit arteries. To explore the hypothesis that shear stress contributes to hypercapnic internal carotid dilation in humans, temporal changes in internal and common carotid shear rate and diameter, along with changes in middle cerebral artery velocity, were simultaneously assessed in 18 subjects at rest and during hypercapnia (6% carbon dioxide). Middle cerebral artery velocity increased significantly (69±10-103±17 cm/s; P
    Original languageEnglish
    Pages (from-to)1217-1224
    JournalHypertension
    Volume68
    Issue number5
    Early online date29 Aug 2016
    DOIs
    Publication statusPublished - Nov 2016

    Fingerprint Dive into the research topics of 'Evidence for shear stress-mediated dilation of the internal carotid artery in humans'. Together they form a unique fingerprint.

    Cite this