Evidence for endogenous exchange of cytoplasmic material between a subset of cone and rod photoreceptors within the adult mammalian retina via direct cell-cell connections

Patrick Heisterkamp, Oliver Borsch, Nundehui Diaz Lezama, Sylvia Gasparini, Adeeba Fathima, Livia S. Carvalho, Felix Wagner, Mike O. Karl, Michael Schlierf, Marius Ader

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Photoreceptor cell transplantation into the mouse retina has been shown to result in the transfer of cytoplasmic material between donor and host photoreceptors. Recently it has been found that this inter-photoreceptor material transfer process is likely to be mediated by nanotube-like structures connecting donor and host photoreceptors. By leveraging cone-specific reporter mice and super-resolution microscopy we provide evidence for the transfer of cytoplasmic material also from endogenous cones to endogenous rod photoreceptors and the existence of nanotube-like cell-cell connections possibly mediating this process in the adult mouse retina, together with preliminary data indicating that horizontal material transfer may also occur in the human retina.

Original languageEnglish
Article number109033
JournalExperimental Eye Research
Volume219
DOIs
Publication statusPublished - Jun 2022

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