Evaluation of the morbidity and mortality associated with anti-nuclear antibodies: what is the predictive value of routinely-collected clinical diagnostic laboratory data?

Research output: ThesisMaster's Thesis

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This study describes a clinical cohort tested for anti-nuclear antibodies (ANA) by indirect immunofluorescence and investigates the utility of quantitated ANA (measured in international units/ml) as a screening test.

ANA were detected in a higher proportion in females. The majority of ANA were low level; increasing level of ANA was associated with an increased likelihood of a dsDNA antibody and antibodies to a number of ENA. ANA had a higher predictive value for these autoantibodies in younger compared to older individuals. ANA pattern and quantitation were significant predictors of morbidity and mortality particularly in musculoskeletal and connective tissue diseases.
Original languageEnglish
Awarding Institution
  • The University of Western Australia
Award date13 Apr 2017
Publication statusUnpublished - 2016


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