Evaluation of Serum C-reactive Protein Levels in Subjects with Aggressive and Chronic Periodontitis in Comparison with Healthy Controls: A Clinico-biochemical Study.

Aim: Evaluation and comparison of serum C‑reactive protein (CRP) levels in subjects with chronic and aggressive periodontitis. Materials and Methods: Based on the periodontal status, 45 subjects were selected and divided into three groups. Group I ‑ subjects with clinically healthy periodontium, Group II ‑ generalized aggressive periodontitis (GAP), and Group III ‑ chronic periodontitis (CP). Blood samples were collected from subjects for measurement of CRP. Periodontal parameters include plaque index (PI), gingival index, bleeding index (BI), probing pocket depth (PPD), and clinical attachment loss (CAL) were assessed. CRP levels were assessed by means of a commercially available high sensitivity‑CRP enzyme immunoassay kit. Results: CRP levels were increased in
Group III (6.0671 ± 3.15639 mg/L) and Group II subjects (4.5453 ± 2.88116 mg/L) compared to the Group I (1.0180 ± 0.94069 mg/L). CRP levels showed a positive correlation with all clinical parameters in Group I subjects. BI (r = 0.073), PI (r = 0.120) showed a positive correlation with CRP level in Group II and a positive correlation was also seen for PI (r = 0.492), PPD (r = 0.340),
CAL (r = 0.160), and CRP level in Group III subjects. Conclusion: The mean CRP levels were found to be greater in CP compared to GAP subjects, but there was no statistically significant difference.