Evaluation of IL12B as a candidate type I diabetes susceptibility gene using data from the Type I Diabetes Genetics Consortium

Grant Morahan, E. Mckinnon, Jemma Berry, B. Browning, C. Julier, F. Pocoit, I. James

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Abstract

As part of its efforts to identify genes affecting the risk of type I diabetes (T1D), the Type I Diabetes Genetics Consortium commissioned an extensive survey of variants associated with genes reported earlier to have an association with disease susceptibility. In this report, we present the analysis of a set of single-nucleotide polymorphisms (SNPs) within and flanking the IL12B gene, which encodes the p40 subunit of the cytokines interleukin (IL)-12 and IL-23. No SNP showed individually significant association in the population as a whole. Nevertheless, subjects stratified according to genotype at the earlier reported SNP in the IL12B 3′UTR, rs3212227, confirmed small, but significant, differences in age of disease onset with a relative hazard=0.88 (P=0.005). The protective effect of rs3212227 allele 2 was gender specific (P=0.004 overall and P=0.0003 when unaffected siblings were considered). Among females, the 2.2 genotype was more protective, with relative hazard=0.75. We conclude that while there was no major effect of IL12B polymorphisms on T1D susceptibility in the entire study group, they have an impact on a subset of at-risk individuals.
Original languageEnglish
Pages (from-to)S64-S68
Number of pages5
JournalGenes and Immunity
Volume10
Issue numbersuppl.1
DOIs
Publication statusPublished - Dec 2009

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Type 1 Diabetes Mellitus
Single Nucleotide Polymorphism
Genotype
Interleukin-12 Subunit p40
Genes
Disease Susceptibility
Age of Onset
Alleles
Cytokines
Population

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Morahan, Grant ; Mckinnon, E. ; Berry, Jemma ; Browning, B. ; Julier, C. ; Pocoit, F. ; James, I. / Evaluation of IL12B as a candidate type I diabetes susceptibility gene using data from the Type I Diabetes Genetics Consortium. In: Genes and Immunity. 2009 ; Vol. 10, No. suppl.1. pp. S64-S68.
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Evaluation of IL12B as a candidate type I diabetes susceptibility gene using data from the Type I Diabetes Genetics Consortium. / Morahan, Grant; Mckinnon, E.; Berry, Jemma; Browning, B.; Julier, C.; Pocoit, F.; James, I.

In: Genes and Immunity, Vol. 10, No. suppl.1, 12.2009, p. S64-S68.

Research output: Contribution to journalArticle

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