Evaluation of diagnostic tests in human health and disease

Ian Martins

Research output: Contribution to specialist publicationArticle in specialist publicationpeer-review

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Mitophagy is a major concern with relevance to chronic
diseases in spite of various plasma/serum clinical chemistry
tests that may provide early diagnosis for the nature of disease.
In health and disease mitochondrial apoptosis is responsible
for apoptotic and necrotic death in various tissues associated
with cardiovascular disease, NAFLD, obesity, diabsetes and
neurodegenerative diseases. Discoveries identify the heat shock
gene Sirt 1 to be defective with toxic immune reactions that
determine mitochondrial survival, mitophagy and mitochondrial
apoptosis. Sirt 1 inactivation in various global chronic diseases
require Sirt 1 plasma analysis to determine effective cell
nuclear-mitochondria DNA methylation in various cells and
tissues that is not evaluated by existing biomedical data from
existing clinical biochemistry diagnostic tests.
Original languageEnglish
Number of pages3
Specialist publicationJournal of Clinical Pathology and Laboratory Medicine
Publication statusPublished - 6 Feb 2018


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