Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1100-1113 |
| Journal | Organic and Biomolecular Chemistry |
| Volume | 12 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2014 |
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Ethynylbenzenoid metabolites of Antrodia camphorata: Synthesis and inhibition of TNF expression. / Buccini, M.; Punch, K.A.; Kaskow, Belinda; Flematti, Gavin; Skelton, Brian; Abraham, Lawrence; Piggott, Matthew.
In: Organic and Biomolecular Chemistry, Vol. 12, No. 7, 2014, p. 1100-1113.Research output: Contribution to journal › Article
TY - JOUR
T1 - Ethynylbenzenoid metabolites of Antrodia camphorata: Synthesis and inhibition of TNF expression
AU - Buccini, M.
AU - Punch, K.A.
AU - Kaskow, Belinda
AU - Flematti, Gavin
AU - Skelton, Brian
AU - Abraham, Lawrence
AU - Piggott, Matthew
PY - 2014
Y1 - 2014
N2 - An improved synthesis of the anti-inflammatory natural product antrocamphin A (2), involving a key Castro-Stephens reaction, is presented, along with the first total synthesis of its congener antrocamphin B (3). Approaches towards the more complex co-metabolite antrodioxolanone (4) were unsuccessful, but a samarium diiodide-mediated pinacol coupling of antrocamphin B did provide the chiral epimers (51). Antrocamphin A (2) inhibits Tumour Necrosis Factor (TNF) reporter gene expression, but its development as an anti-inflammatory agent may be limited by cytotoxicity. This journal is © The Royal Society of Chemistry.
AB - An improved synthesis of the anti-inflammatory natural product antrocamphin A (2), involving a key Castro-Stephens reaction, is presented, along with the first total synthesis of its congener antrocamphin B (3). Approaches towards the more complex co-metabolite antrodioxolanone (4) were unsuccessful, but a samarium diiodide-mediated pinacol coupling of antrocamphin B did provide the chiral epimers (51). Antrocamphin A (2) inhibits Tumour Necrosis Factor (TNF) reporter gene expression, but its development as an anti-inflammatory agent may be limited by cytotoxicity. This journal is © The Royal Society of Chemistry.
U2 - 10.1039/c3ob42333f
DO - 10.1039/c3ob42333f
M3 - Article
VL - 12
SP - 1100
EP - 1113
JO - Organic & Biomolecular Chemistry
JF - Organic & Biomolecular Chemistry
SN - 1477-0520
IS - 7
ER -