Ethnicity Does Not Affect the Homocysteine-Lowering effect of B-Vitamin Therapy in Singaporean Stroke Patients

K. Kasiman, J.W. Eikelboom, Graeme Hankey, S.P-K. Lee, J.P-Z. Lim, J.H-Q. Lee, H-M. Chang, M-C. Wong, C. Chen

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    Abstract

    Background and Purpose— Increased total homocysteine (tHcy) is a risk factor for stroke. This study examines whether the efficacy of B-vitamins in reducing tHcy is modified by ethnicity in a Singaporean ischemic stroke population.Methods— 505 patients (419 Chinese, 41 Malays and 45 Indians) with ischemic stroke were randomized to receive placebo or B-vitamins. Fasting blood samples collected at baseline and 1 year were assayed for tHcy. MTHFR polymorphisms were genotyped.Results— Ethnicity did not independently determine tHcy at baseline. The magnitude of tHcy reduction by B-vitamin treatment was consistent across ethnic groups (Chinese −3.8±4.5, Malay −4.9±4.2, and Indian −3.3±3.6μmol/L) despite ethnic differences in MTHFR genotype and baseline folic acid (FA) and vitamin B12 (vitB12) concentrations.Conclusions— Ethnicity does not appear to affect the tHcy-lowering effect of B-vitamins, despite differences in dietary intake and prevalence of MTHFR polymorphisms. This suggests that the effect of B-vitamins in lowering tHcy is generalizable across Asian populations. However, due to relatively small numbers of non-Chinese studied, confirmation in other populations is required.
    Original languageEnglish
    Pages (from-to)2209-2211
    JournalStroke
    Volume40
    Issue number6
    DOIs
    Publication statusPublished - 2009

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