Estimation of the latent therapeutic demand for albumin in the USA: a focus on three indications

Albert Farrugia, M. Bansal

Research output: Contribution to journalAbstract/Meeting Abstractpeer-review



The use of albumin in therapeutics is controversial in several areas and requires assessment based on evidence for effective resource allocation. Supported indications include sepsis, areas of hepatic diseases and coronary artery bypass grafts (CABG). Latent therapeutic demand (LTD) [1] is the underlying evidence-based demand ensuring ample supplies of drugs are available and affordable. Estimating the LTD would assist decision-making and resource allocation, but many of the clinical and epidemiologic variables are subject to uncertainty. Decision analysis [2] may assist in generating an assessment of the demand for albumin.


A decision analysis model was constructed using Excel. The model is based on the relationships of the epidemiological and clinical factors . Data for the individual factors were obtained from the literature. One-way sensitivity analysis was used to generate Tornado diagrams (exemplified in Figure ​Figure22 for albumin use in sepsis) to determine the relative contribution of different factors to the LTD. Probabilistic sensitivity analysis was used to generate a probability distribution and calculate a mean level for the LTD of each indication.


On average, albumin use was calculated as 104 g per 1,000 inhabitants in severe sepsis, 157 g per 1,000 inhabitants in liver diseases and 61 g per 1,000 inhabitants in CABG. This shows a total LTD of 322 g per 1,000 use of albumin in the US annually.


Albumin consumption in the USA currently averages 479 g per 1,000 population [3]. Hence, the LTD of these three evidence-based indications represents 67% of current usage. Further work is needed to assess the LTD for albumin in other, less well-defined areas.


Stonebraker J, J Clin Immunol. 2014. pp. 233–44. [PubMed] [Cross Ref]
Goel V. CMAJ. 1992. pp. 413–7. [PMC free article] [PubMed]
Market Research Bureau. The plasma proteins market in the USA (2013)
Original languageEnglish
JournalCritical Care
Publication statusPublished - 2015


Dive into the research topics of 'Estimation of the latent therapeutic demand for albumin in the USA: a focus on three indications'. Together they form a unique fingerprint.

Cite this