Projects per year
Abstract
Purpose: To consider the effect of including past sun exposure in estimating heritability and familial correlation of myopia-related traits. Methods: We calculate the familial correlation and heritability of anterior chamber depth (ACD), axial length (AL), corneal curvature (CC) and spherical equivalent (SphE), with or without past sun exposure as a covariate, in a large number of unrelated nuclear families from the Raine Study (parents: Gen1, offspring: Gen2) residing in Perth, Australia, a city with a high amount of daily sunlight. Past sun exposure was objectively measured using conjunctival ultraviolet autofluorescence (CUVAF) photography. Results: When sun exposure was not included in the analysis, both familial correlation (correlation±SE; ACD: 0.308±0.065, AL: 0.374±0.061, CC: 0.436±0.063, SphE: 0.281±0.070) and heritability (ACD: 0.606±0.104, AL: 0.623±0.098, CC: 0.793±0.079, SphE: 0.591±0.106) were significant (all P < 0.001) for all traits. However, there was no significant change in both familial correlation and heritability estimates when sun exposure was included as an additional covariate. Conclusions: Past sun exposure does not affect the estimation of the additive genetic component in myopia-related traits.
Original language | English |
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Pages (from-to) | 500-506 |
Number of pages | 7 |
Journal | Ophthalmic Genetics |
Volume | 40 |
Issue number | 6 |
DOIs | |
Publication status | Published - 6 Dec 2019 |
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Dive into the research topics of 'Estimation of heritability and familial correlation in myopia is not affected by past sun exposure'. Together they form a unique fingerprint.Projects
- 2 Finished
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Understanding, Predicting, Preventing and Treating the highly heritable, common eye diseases Myopia and Glaucoma to reduce Blindness and Visual Impairment
Mackey, D. (Investigator 01)
NHMRC National Health and Medical Research Council
1/01/19 → 29/02/24
Project: Research
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Young adult myopia: genetic and environmental associations
Mackey, D. (Investigator 01), Sanfilippo, P. (Investigator 02), Hammond, C. (Investigator 03), Yazar, S. (Investigator 04), Rose, K. (Investigator 05), Milne, E. (Investigator 06), Lucas, R. (Investigator 07) & Chen, F. (Investigator 08)
NHMRC National Health and Medical Research Council
1/01/17 → 31/12/21
Project: Research