Establishment of Wolbachia Strain wAlbB in Malaysian Populations of Aedes aegypti for Dengue Control

Wasi A. Nazni; Ary A. Hoffmann; Ahmad NoorAfizah; Yoon Ling Cheong; Maria V. Mancini; Nicholas Golding; Ghazali M.R. Kamarul; Mohd A.K. Arif; Hasim Thohir; Halim NurSyamimi; M. Zabari ZatilAqmar; Mazni NurRuqqayah; Amran NorSyazwani; Azmi Faiz; Francis Rudin M.N. Irfan; Subramaniam Rubaaini; Nasir Nuradila; Nasir M.N. Nizam; Saidin M. Irwan; Nancy M. Endersby-Harshman; Vanessa L. White; Thomas H. Ant; Christie S. Herd; Asim H. Hasnor; Rahman AbuBakar; Dusa M. Hapsah; Khairuddin Khadijah; Denim Kamilan; Soo Cheng Lee; Yusof M. Paid; Kamaludin Fadzilah; Omar Topek; Balvinder S. Gill; Han Lim Lee; Steven P. Sinkins

doi:10.1016/j.cub.2019.11.007

Establishment of Wolbachia Strain wAlbB in Malaysian Populations of Aedes aegypti for Dengue Control

Wasi A. Nazni
, Ary A. Hoffmann
, Ahmad NoorAfizah
, Yoon Ling Cheong
, Maria V. Mancini
, Nicholas Golding
, Ghazali M.R. Kamarul
, Mohd A.K. Arif
, Hasim Thohir
, Halim NurSyamimi
, M. Zabari ZatilAqmar
, Mazni NurRuqqayah
, Amran NorSyazwani
, Azmi Faiz
, Francis Rudin M.N. Irfan
, Subramaniam Rubaaini
, Nasir Nuradila
, Nasir M.N. Nizam
, Saidin M. Irwan
, Nancy M. Endersby-Harshman

Vanessa L. White, Thomas H. Ant, Christie S. Herd, Asim H. Hasnor, Rahman AbuBakar, Dusa M. Hapsah, Khairuddin Khadijah, Denim Kamilan, Soo Cheng Lee, Yusof M. Paid, Kamaludin Fadzilah, Omar Topek, Balvinder S. Gill, Han Lim Lee, Steven P. Sinkins

Research output: Contribution to journal › Article › peer-review

290 Citations (Scopus)

Abstract

Dengue has enormous health impacts globally. A novel approach to decrease dengue incidence involves the introduction of Wolbachia endosymbionts that block dengue virus transmission into populations of the primary vector mosquito, Aedes aegypti. The wMel Wolbachia strain has previously been trialed in open releases of Ae. aegypti; however, the wAlbB strain has been shown to maintain higher density than wMel at high larval rearing temperatures. Releases of Ae. aegypti mosquitoes carrying wAlbB were carried out in 6 diverse sites in greater Kuala Lumpur, Malaysia, with high endemic dengue transmission. The strain was successfully established and maintained at very high population frequency at some sites or persisted with additional releases following fluctuations at other sites. Based on passive case monitoring, reduced human dengue incidence was observed in the release sites when compared to control sites. The wAlbB strain of Wolbachia provides a promising option as a tool for dengue control, particularly in very hot climates.

Original language	English
Article number	e5
Number of pages	14
Journal	Current Biology
Volume	29
Issue number	24
DOIs	https://doi.org/10.1016/j.cub.2019.11.007
Publication status	Published - 21 Nov 2019
Externally published	Yes

Funding

Funders	Funder number
NHMRC National Health and Medical Research Council	1132412, 1118640

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.cub.2019.11.007Licence: CC BY

Cite this

Nazni, W. A., Hoffmann, A. A., NoorAfizah, A., Cheong, Y. L., Mancini, M. V., Golding, N., Kamarul, G. M. R., Arif, M. A. K., Thohir, H., NurSyamimi, H., ZatilAqmar, M. Z., NurRuqqayah, M., NorSyazwani, A., Faiz, A., Irfan, F. R. M. N., Rubaaini, S., Nuradila, N., Nizam, N. M. N., Irwan, S. M., ... Sinkins, S. P. (2019). Establishment of Wolbachia Strain wAlbB in Malaysian Populations of Aedes aegypti for Dengue Control. Current Biology, 29(24), Article e5. https://doi.org/10.1016/j.cub.2019.11.007

@article{2f286076fa2f41b9b8f5f4c62ad06fd6,

title = "Establishment of Wolbachia Strain wAlbB in Malaysian Populations of Aedes aegypti for Dengue Control",

abstract = "Dengue has enormous health impacts globally. A novel approach to decrease dengue incidence involves the introduction of Wolbachia endosymbionts that block dengue virus transmission into populations of the primary vector mosquito, Aedes aegypti. The wMel Wolbachia strain has previously been trialed in open releases of Ae. aegypti; however, the wAlbB strain has been shown to maintain higher density than wMel at high larval rearing temperatures. Releases of Ae. aegypti mosquitoes carrying wAlbB were carried out in 6 diverse sites in greater Kuala Lumpur, Malaysia, with high endemic dengue transmission. The strain was successfully established and maintained at very high population frequency at some sites or persisted with additional releases following fluctuations at other sites. Based on passive case monitoring, reduced human dengue incidence was observed in the release sites when compared to control sites. The wAlbB strain of Wolbachia provides a promising option as a tool for dengue control, particularly in very hot climates.",

keywords = "Aedes, arbovirus, dengue, disease reduction, mosquito, Wolbachia bacteria",

author = "Nazni, \{Wasi A.\} and Hoffmann, \{Ary A.\} and Ahmad NoorAfizah and Cheong, \{Yoon Ling\} and Mancini, \{Maria V.\} and Nicholas Golding and Kamarul, \{Ghazali M.R.\} and Arif, \{Mohd A.K.\} and Hasim Thohir and Halim NurSyamimi and ZatilAqmar, \{M. Zabari\} and Mazni NurRuqqayah and Amran NorSyazwani and Azmi Faiz and Irfan, \{Francis Rudin M.N.\} and Subramaniam Rubaaini and Nasir Nuradila and Nizam, \{Nasir M.N.\} and Irwan, \{Saidin M.\} and Endersby-Harshman, \{Nancy M.\} and White, \{Vanessa L.\} and Ant, \{Thomas H.\} and Herd, \{Christie S.\} and Hasnor, \{Asim H.\} and Rahman AbuBakar and Hapsah, \{Dusa M.\} and Khairuddin Khadijah and Denim Kamilan and Lee, \{Soo Cheng\} and Paid, \{Yusof M.\} and Kamaludin Fadzilah and Omar Topek and Gill, \{Balvinder S.\} and Lee, \{Han Lim\} and Sinkins, \{Steven P.\}",

note = "Publisher Copyright: {\textcopyright} 2019",

year = "2019",

month = nov,

day = "21",

doi = "10.1016/j.cub.2019.11.007",

language = "English",

volume = "29",

journal = "Current Biology",

issn = "0960-9822",

publisher = "Cell Press",

number = "24",

}

Nazni, WA, Hoffmann, AA, NoorAfizah, A, Cheong, YL, Mancini, MV, Golding, N, Kamarul, GMR, Arif, MAK, Thohir, H, NurSyamimi, H, ZatilAqmar, MZ, NurRuqqayah, M, NorSyazwani, A, Faiz, A, Irfan, FRMN, Rubaaini, S, Nuradila, N, Nizam, NMN, Irwan, SM, Endersby-Harshman, NM, White, VL, Ant, TH, Herd, CS, Hasnor, AH, AbuBakar, R, Hapsah, DM, Khadijah, K, Kamilan, D, Lee, SC, Paid, YM, Fadzilah, K, Topek, O, Gill, BS, Lee, HL & Sinkins, SP 2019, 'Establishment of Wolbachia Strain wAlbB in Malaysian Populations of Aedes aegypti for Dengue Control', Current Biology, vol. 29, no. 24, e5. https://doi.org/10.1016/j.cub.2019.11.007

TY - JOUR

T1 - Establishment of Wolbachia Strain wAlbB in Malaysian Populations of Aedes aegypti for Dengue Control

AU - Nazni, Wasi A.

AU - Hoffmann, Ary A.

AU - NoorAfizah, Ahmad

AU - Cheong, Yoon Ling

AU - Mancini, Maria V.

AU - Golding, Nicholas

AU - Kamarul, Ghazali M.R.

AU - Arif, Mohd A.K.

AU - Thohir, Hasim

AU - NurSyamimi, Halim

AU - ZatilAqmar, M. Zabari

AU - NurRuqqayah, Mazni

AU - NorSyazwani, Amran

AU - Faiz, Azmi

AU - Irfan, Francis Rudin M.N.

AU - Rubaaini, Subramaniam

AU - Nuradila, Nasir

AU - Nizam, Nasir M.N.

AU - Irwan, Saidin M.

AU - Endersby-Harshman, Nancy M.

AU - White, Vanessa L.

AU - Ant, Thomas H.

AU - Herd, Christie S.

AU - Hasnor, Asim H.

AU - AbuBakar, Rahman

AU - Hapsah, Dusa M.

AU - Khadijah, Khairuddin

AU - Kamilan, Denim

AU - Lee, Soo Cheng

AU - Paid, Yusof M.

AU - Fadzilah, Kamaludin

AU - Topek, Omar

AU - Gill, Balvinder S.

AU - Lee, Han Lim

AU - Sinkins, Steven P.

PY - 2019/11/21

Y1 - 2019/11/21

N2 - Dengue has enormous health impacts globally. A novel approach to decrease dengue incidence involves the introduction of Wolbachia endosymbionts that block dengue virus transmission into populations of the primary vector mosquito, Aedes aegypti. The wMel Wolbachia strain has previously been trialed in open releases of Ae. aegypti; however, the wAlbB strain has been shown to maintain higher density than wMel at high larval rearing temperatures. Releases of Ae. aegypti mosquitoes carrying wAlbB were carried out in 6 diverse sites in greater Kuala Lumpur, Malaysia, with high endemic dengue transmission. The strain was successfully established and maintained at very high population frequency at some sites or persisted with additional releases following fluctuations at other sites. Based on passive case monitoring, reduced human dengue incidence was observed in the release sites when compared to control sites. The wAlbB strain of Wolbachia provides a promising option as a tool for dengue control, particularly in very hot climates.

AB - Dengue has enormous health impacts globally. A novel approach to decrease dengue incidence involves the introduction of Wolbachia endosymbionts that block dengue virus transmission into populations of the primary vector mosquito, Aedes aegypti. The wMel Wolbachia strain has previously been trialed in open releases of Ae. aegypti; however, the wAlbB strain has been shown to maintain higher density than wMel at high larval rearing temperatures. Releases of Ae. aegypti mosquitoes carrying wAlbB were carried out in 6 diverse sites in greater Kuala Lumpur, Malaysia, with high endemic dengue transmission. The strain was successfully established and maintained at very high population frequency at some sites or persisted with additional releases following fluctuations at other sites. Based on passive case monitoring, reduced human dengue incidence was observed in the release sites when compared to control sites. The wAlbB strain of Wolbachia provides a promising option as a tool for dengue control, particularly in very hot climates.

KW - Aedes

KW - arbovirus

KW - dengue

KW - disease reduction

KW - mosquito

KW - Wolbachia bacteria

UR - https://www.scopus.com/pages/publications/85076236509

U2 - 10.1016/j.cub.2019.11.007

DO - 10.1016/j.cub.2019.11.007

M3 - Article

C2 - 31761702

AN - SCOPUS:85076236509

SN - 0960-9822

VL - 29

JO - Current Biology

JF - Current Biology

IS - 24

M1 - e5

ER -

Establishment of Wolbachia Strain wAlbB in Malaysian Populations of Aedes aegypti for Dengue Control

Abstract

Funding

UN SDGs

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