Establishment of The Gene Mile : a resource for rapid identification of complex trait genes

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Identification of genes underlying complex traits presents a challenge to which geneticists have responded with many diverse approaches. A common feature of these approaches is that different research groupsmust, on a case-by-case basis, replicate similar efforts in recruitment, genetic characterization, and analyses. To avoid this expensive ‘‘churning,’’ an alternative approach has been proposed: production of an experimental genetic reference population, the Collaborative Cross, in which both genetic diversity and mapping power are maximized. Since this population consists of inbred mouse strains, further advantages are that it is essentially infinitely reproducible;genetic characterization needs to be performed only once; and the founder strains’ genomes have been or will be sequenced, allowing imputation of allele sequences of all members of the reference population. Here we describe the establishment of such a genetic reference population, which we dub ‘‘The Gene Mine.’’ Over 1000 genetically distinct lines have been established, descended from eight diverse founder strains. Preliminary phenotypic ascertainment ofthese strains indicates unexpected variability arising fromindependent assortment of genetic variants. The Gene Mine will be a powerful resource for characterization of essentially any mouse phenotype that has a genetic basis.
Original languageEnglish
Pages (from-to)390-393
JournalMammalian Genome
Volume19
Issue number6
DOIs
Publication statusPublished - 2008

Fingerprint Dive into the research topics of 'Establishment of The Gene Mile : a resource for rapid identification of complex trait genes'. Together they form a unique fingerprint.

  • Cite this