Establishment of the early-life microbiome: A DOHaD perspective

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The human microbiome plays a number of critical roles in host physiology. Evidence from longitudinal cohort studies and animal models strongly supports the theory that maldevelopment of the microbiome in early life can programme later-life disease. The early-life microbiome develops in a clear stepwise manner over the first 3 years of life. During this highly dynamic time, insults such as antibiotic use and formula feeding can adversely affect the composition and temporal development of the microbiome. Such experiences predispose infants for the development of chronic health conditions later in life. This review highlights key factors that disrupt the early-life microbiome and highlights major non-communicable diseases which are underpinned by early-life dysbiosis.

Original languageEnglish
Pages (from-to)201-210
Number of pages10
JournalJournal of Developmental Origins of Health and Disease
Issue number3
Early online date11 Oct 2019
Publication statusPublished - 1 Jun 2020


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