TY - JOUR
T1 - Establishment of an induced pluripotent stem cell line from a retinitis pigmentosa patient with compound heterozygous CRB1 mutation
AU - Zhang, Xiao
AU - Zhang, Dan
AU - Chen, Shang Chih
AU - Lamey, Tina
AU - Thompson, Jennifer A.
AU - McLaren, Terri
AU - De Roach, John N.
AU - Chen, Fred K.
AU - McLenachan, Samuel
PY - 2018/8/1
Y1 - 2018/8/1
N2 - The human iPSC line LEIi006-A was generated from dermal fibroblasts from a patient with retinitis pigmentosa using episomal plasmids containing OCT4, SOX2, KLF4, L-MYC, LIN28, mir302/367 microRNA and shRNA for p53. The iPSC cells carry compound heterozygous mutations (c.1892A > G and c.2548G > A) in the CRB1 gene. LEIi006-A expressed pluripotent stem cell markers, had a normal karyotype and could be differentiated into endoderm, mesoderm and ectodermal lineages, as well as retinal organoids.
AB - The human iPSC line LEIi006-A was generated from dermal fibroblasts from a patient with retinitis pigmentosa using episomal plasmids containing OCT4, SOX2, KLF4, L-MYC, LIN28, mir302/367 microRNA and shRNA for p53. The iPSC cells carry compound heterozygous mutations (c.1892A > G and c.2548G > A) in the CRB1 gene. LEIi006-A expressed pluripotent stem cell markers, had a normal karyotype and could be differentiated into endoderm, mesoderm and ectodermal lineages, as well as retinal organoids.
UR - http://www.scopus.com/inward/record.url?scp=85050985031&partnerID=8YFLogxK
U2 - 10.1016/j.scr.2018.08.001
DO - 10.1016/j.scr.2018.08.001
M3 - Article
AN - SCOPUS:85050985031
SN - 1873-5061
VL - 31
SP - 147
EP - 151
JO - Stem Cell Research
JF - Stem Cell Research
ER -