Establishing causality for Cdkn2a loss in liver progenitor cell transformation as a mechanism for hepatocarcinogenesis

Robyn Patricia Strauss

Research output: ThesisDoctoral Thesis

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Abstract

The CDKN2A gene is frequently mutated or methylated in Hepatocellular carcinomas. Indeed, we observed the two tumour suppressors encoded by CDKN2A, ARF and INK4A, were consistently diminished following the tumorigenic transformation of putative liver cancer stem cell, liver progenitor cells (LPCs). This thesis examined the causality of CDKN2A loss in murine LPC transformation utilising multiple in vitro and in vivo approaches. The data presented provide compelling evidence that the loss of ARF and INK4A enhances the propensity of LPCs to undergo a tumorigenic transformation and affects liver homeostasis.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Award date24 Oct 2017
DOIs
Publication statusUnpublished - 2017

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