Escapees from Rhombomeric Lineage Restriction: Extensive Migration Rostral to the r4/r5 Border of Hox-a3 Expression

Charles Watson, Gayeshika Leanage, Nadja Makki, Petr Tvrdik

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The rhombomeric compartments of the hindbrain are characterized by lineage restriction; cells born in one compartment generally remain there and do not migrate to neighboring rhombomeres. Two well-known exceptions are the substantial migrations of the pontine nuclei and the mammalian facial nucleus. In this study we used Hoxa3-Cre lineage to permanently mark cells that originate in rhombomeres caudal to r4. We found that cells born caudal to the r4/r5 border migrate forwards to a number of different locations in rhombomeres 1–4; the final locations include the interfascicular trigeminal nucleus, the principal trigeminal nucleus, the pontine nuclei, the reticulotegmental nucleus, the ventral nucleus of the lateral lemniscus, and the lateral and medial vestibular nuclei. We suggest that there are numerous exceptions to the principle of rhombomeric lineage restriction that have previously gone unnoticed. Anat Rec, 2017.

Original languageEnglish
Pages (from-to)1838-1846
Number of pages9
JournalAnatomical Record
Volume300
Issue number10
DOIs
Publication statusPublished - 1 Oct 2017
Externally publishedYes

Fingerprint Dive into the research topics of 'Escapees from Rhombomeric Lineage Restriction: Extensive Migration Rostral to the r4/r5 Border of Hox-a3 Expression'. Together they form a unique fingerprint.

  • Cite this