TY - JOUR
T1 - Erectile dysfunction predicts generalised cardiovascular disease: Evidence from a case-control study
AU - Stuckey, Bronwyn
AU - Walsh, John
AU - Ching, H.L.
AU - Stuckey, A.W.
AU - Palmer, N.R.
AU - Thompson, Peter
AU - Watts, Gerald
PY - 2007
Y1 - 2007
N2 - Aims: To determine whether idiopathic erectile dysfunction, in the absence of overt cardiovascular disease or cardiovascular risk factors, is associated with vascular or autonomic dysfunction.Methods: We studied 49 men with ED (without known cardiovascular risk factors or disease) and 50 age-matched controls, aged 40-70 years. Macrovascular endothelial function was examined by brachial artery ultrasonography and microvascular function by venous occlusion plethysmography. Blood pressure measurement and electrocardiography were performed lying and standing, and the 30:15 RR ratio calculated.Results: Body mass index, testosterone, fasting lipids and glucose did not differ significantly between groups. Standing pulse pressure was higher (50 +/- 1 mm Hg versus 43 +/- 2 mm Hg, p < 0.004) and 30:15 RR ratio lower (0.97 +/- 0.01 versus 1.01 +/- 0.01, p < 0.02) in the ED group. Flow-mediated dilatation of the brachial artery was not significantly different between groups. Flow debt repayment during forearm reactive hyperaemia was lower in the ED group (7.2 +/- 10.7 ml versus 9.5 +/- 0.8 ml per 100 ml, p < 0.02) than in controls.Conclusions: Men with idiopathic ED have evidence of endothelial dysfunction in forearm resistance vessels, increased pulse pressure and impaired heart rate variability. This supports the concept that erectile dysfunction is a predictor of cardiovascular dysfunction and a precursor of clinical cardiovascular disease. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
AB - Aims: To determine whether idiopathic erectile dysfunction, in the absence of overt cardiovascular disease or cardiovascular risk factors, is associated with vascular or autonomic dysfunction.Methods: We studied 49 men with ED (without known cardiovascular risk factors or disease) and 50 age-matched controls, aged 40-70 years. Macrovascular endothelial function was examined by brachial artery ultrasonography and microvascular function by venous occlusion plethysmography. Blood pressure measurement and electrocardiography were performed lying and standing, and the 30:15 RR ratio calculated.Results: Body mass index, testosterone, fasting lipids and glucose did not differ significantly between groups. Standing pulse pressure was higher (50 +/- 1 mm Hg versus 43 +/- 2 mm Hg, p < 0.004) and 30:15 RR ratio lower (0.97 +/- 0.01 versus 1.01 +/- 0.01, p < 0.02) in the ED group. Flow-mediated dilatation of the brachial artery was not significantly different between groups. Flow debt repayment during forearm reactive hyperaemia was lower in the ED group (7.2 +/- 10.7 ml versus 9.5 +/- 0.8 ml per 100 ml, p < 0.02) than in controls.Conclusions: Men with idiopathic ED have evidence of endothelial dysfunction in forearm resistance vessels, increased pulse pressure and impaired heart rate variability. This supports the concept that erectile dysfunction is a predictor of cardiovascular dysfunction and a precursor of clinical cardiovascular disease. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
U2 - 10.1016/j.atherosclerosis.2006.08.043
DO - 10.1016/j.atherosclerosis.2006.08.043
M3 - Article
VL - 194
SP - 458
EP - 464
JO - Journal of Atherosclerosis
JF - Journal of Atherosclerosis
SN - 0021-9150
IS - 2
ER -