Eradication of Helicobacter pylori, starting with rational use of antibiotics

Ren Xiaoying, Xuehong Li, Zhang Shuzhen, Wang Xiangyu, Sylvia Young, Barry Marshall, Chin Yen Tay

Research output: Contribution to journalReview articlepeer-review

Abstract

Antibiotic resistance is the primary cause of treatment failure on Helicobacter pylori infection. Due to a large number of clinicians involved in the treatment of Helicobacter pylori infection in China, the irregular treatment, and the overuse of antibiotics, the resistance rate of Helicobacter pylori to various antibiotics has gradually increased, leading to the decline of successful treatment of Helicobacter pylori infection. In order to improve the eradication rate of Helicobacter pylori and combat antibiotic resistance, this review summarizes the pharmacological mechanism of seven antibiotics which are currently used for Helicobacter pylori treatment. In addition, this review also evaluates the antibiotic resistance genes associated with each of the recommended drugs to help clinicians gain a deeper understanding of the drug choices. Lastly, in regions where antibiotic resistance is common, we encourage clinical doctors to provide antibiotic susceptibility guided treatment to improve treatment success rate, reduce the emergence of resistant strains, shorten the treatment process, avoid the waste of medical resources, improve the Helicobacter pylori eradication rate, reduce the recurrence of peptic ulcer, delay the process of MALT lymphoma, prevent gastric cancer, and benefit the patients.
Original languageEnglish
Pages (from-to)38-42
Number of pages5
JournalElectronic Journal of Emerging Infectious Diseases
Volume5
Issue number1
Publication statusPublished - 22 Apr 2020

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