Epithelium-derived inhibitory prostaglandins modulate human bronchial smooth muscle responses to histamine

D.A. Knight, Geoffrey Lai, G.A. Stewart, Philip Thompson

    Research output: Contribution to journalArticle

    21 Citations (Scopus)

    Abstract

    The role of the bronchial epithelium and inhibitory prostaglandins in the induction of histamine tachyphylaxis in human isolated bronchial smooth muscle was investigated using bronchi obtained from 14 patients who had been treated with non-steroidal anti-inflammatory drugs (NSAID) for > 2 months and from 14 untreated patients. Epithelium-intact bronchial strips from untreated patients demonstrated tachyphylaxis to histamine with the maximum response (E(max)) reduced by 30 +/- 5% (P
    Original languageEnglish
    Pages (from-to)1-12
    JournalEuropean Journal of Pharmacology
    Volume272
    Issue number1
    DOIs
    Publication statusPublished - 1995

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