Epithelioid angiosarcoma arising in an adrenal cortical adenoma: A case report and review of the literature

S. Hendry, Cynthia Forrest

    Research output: Contribution to journalReview article

    7 Citations (Scopus)

    Abstract

    © The Author(s) 2014. Adrenal masses are common incidental imaging findings, with the majority comprising benign adrenal cortical adenomas. However, the differential diagnosis is extensive and includes both primary and secondary malignant lesions. Primary adrenal angiosarcomas are rare and often exhibit epithelioid morphology, which can present a diagnostic pitfall. We report an exceptional "incidentaloma" in a 60-year-old lady, which showed the features of a primary epithelioid angiosarcoma arising within an adrenal cortical adenoma. No other primary tumor was identified on extensive imaging. This unusual combined tumor has been reported only once before, to the best of our knowledge. The pattern of infiltration of the malignant endothelial cells raises the suggestion that the angiosarcoma arose from vascular elements of the adenoma.
    Original languageEnglish
    Pages (from-to)744-748
    JournalInternational Journal of Surgical Pathology
    Volume22
    Issue number8
    DOIs
    Publication statusPublished - 2014

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    Adrenocortical Adenoma
    Hemangiosarcoma
    Incidental Findings
    Adenoma
    Blood Vessels
    Neoplasms
    Differential Diagnosis
    Endothelial Cells

    Cite this

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    abstract = "{\circledC} The Author(s) 2014. Adrenal masses are common incidental imaging findings, with the majority comprising benign adrenal cortical adenomas. However, the differential diagnosis is extensive and includes both primary and secondary malignant lesions. Primary adrenal angiosarcomas are rare and often exhibit epithelioid morphology, which can present a diagnostic pitfall. We report an exceptional {"}incidentaloma{"} in a 60-year-old lady, which showed the features of a primary epithelioid angiosarcoma arising within an adrenal cortical adenoma. No other primary tumor was identified on extensive imaging. This unusual combined tumor has been reported only once before, to the best of our knowledge. The pattern of infiltration of the malignant endothelial cells raises the suggestion that the angiosarcoma arose from vascular elements of the adenoma.",
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    Epithelioid angiosarcoma arising in an adrenal cortical adenoma: A case report and review of the literature. / Hendry, S.; Forrest, Cynthia.

    In: International Journal of Surgical Pathology, Vol. 22, No. 8, 2014, p. 744-748.

    Research output: Contribution to journalReview article

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    AU - Forrest, Cynthia

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    N2 - © The Author(s) 2014. Adrenal masses are common incidental imaging findings, with the majority comprising benign adrenal cortical adenomas. However, the differential diagnosis is extensive and includes both primary and secondary malignant lesions. Primary adrenal angiosarcomas are rare and often exhibit epithelioid morphology, which can present a diagnostic pitfall. We report an exceptional "incidentaloma" in a 60-year-old lady, which showed the features of a primary epithelioid angiosarcoma arising within an adrenal cortical adenoma. No other primary tumor was identified on extensive imaging. This unusual combined tumor has been reported only once before, to the best of our knowledge. The pattern of infiltration of the malignant endothelial cells raises the suggestion that the angiosarcoma arose from vascular elements of the adenoma.

    AB - © The Author(s) 2014. Adrenal masses are common incidental imaging findings, with the majority comprising benign adrenal cortical adenomas. However, the differential diagnosis is extensive and includes both primary and secondary malignant lesions. Primary adrenal angiosarcomas are rare and often exhibit epithelioid morphology, which can present a diagnostic pitfall. We report an exceptional "incidentaloma" in a 60-year-old lady, which showed the features of a primary epithelioid angiosarcoma arising within an adrenal cortical adenoma. No other primary tumor was identified on extensive imaging. This unusual combined tumor has been reported only once before, to the best of our knowledge. The pattern of infiltration of the malignant endothelial cells raises the suggestion that the angiosarcoma arose from vascular elements of the adenoma.

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