Epistasis Between Type 2 Diabetes Susceptibility Loci on Chromosomes 1q21-25 and 10q23-26 in Northern Europeans

Steve Wiltshire; J.T. Bell; C.J. Groves; C. Dina; A.T. Hattersley; T.M. Frayling; M. Walker; G.A. Hitman; M. Vaxillaire; M. Farrall; P. Froguel; M.I. Mccarthy

doi:10.1111/j.1469-1809.2006.00289.x

Epistasis Between Type 2 Diabetes Susceptibility Loci on Chromosomes 1q21-25 and 10q23-26 in Northern Europeans

Steve Wiltshire, J.T. Bell, C.J. Groves, C. Dina, A.T. Hattersley, T.M. Frayling, M. Walker, G.A. Hitman, M. Vaxillaire, M. Farrall, P. Froguel, M.I. Mccarthy

UWA Centre for Medical Research (affiliated with the Harry Perkins Institute of Medical Research)

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Characterisation of the interactions between susceptibility loci (epistasis) is central to a full understanding of the genetic aetiology and the molecular pathology of complex diseases. We have examined, in British and French pedigrees, evidence for epistasis between the type 2 diabetes susceptibility loci on chromosomes 1q21-25 and 10q23-26 using two complementary linkage-based approaches. Joint two-locus linkage analysis of 1q and 10q in British pedigrees provided significant evidence for interaction (P

Original language	English
Pages (from-to)	726-737
Journal	Annals of Human Genetics
Volume	70
DOIs	https://doi.org/10.1111/j.1469-1809.2006.00289.x
Publication status	Published - 2006

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Wiltshire, S., Bell, J. T., Groves, C. J., Dina, C., Hattersley, A. T., Frayling, T. M., Walker, M., Hitman, G. A., Vaxillaire, M., Farrall, M., Froguel, P., & Mccarthy, M. I. (2006). Epistasis Between Type 2 Diabetes Susceptibility Loci on Chromosomes 1q21-25 and 10q23-26 in Northern Europeans. Annals of Human Genetics, 70, 726-737. https://doi.org/10.1111/j.1469-1809.2006.00289.x

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abstract = "Characterisation of the interactions between susceptibility loci (epistasis) is central to a full understanding of the genetic aetiology and the molecular pathology of complex diseases. We have examined, in British and French pedigrees, evidence for epistasis between the type 2 diabetes susceptibility loci on chromosomes 1q21-25 and 10q23-26 using two complementary linkage-based approaches. Joint two-locus linkage analysis of 1q and 10q in British pedigrees provided significant evidence for interaction (P",

author = "Steve Wiltshire and J.T. Bell and C.J. Groves and C. Dina and A.T. Hattersley and T.M. Frayling and M. Walker and G.A. Hitman and M. Vaxillaire and M. Farrall and P. Froguel and M.I. Mccarthy",

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T1 - Epistasis Between Type 2 Diabetes Susceptibility Loci on Chromosomes 1q21-25 and 10q23-26 in Northern Europeans

AU - Wiltshire, Steve

AU - Bell, J.T.

AU - Groves, C.J.

AU - Dina, C.

AU - Hattersley, A.T.

AU - Frayling, T.M.

AU - Walker, M.

AU - Hitman, G.A.

AU - Vaxillaire, M.

AU - Farrall, M.

AU - Froguel, P.

AU - Mccarthy, M.I.

PY - 2006

Y1 - 2006

N2 - Characterisation of the interactions between susceptibility loci (epistasis) is central to a full understanding of the genetic aetiology and the molecular pathology of complex diseases. We have examined, in British and French pedigrees, evidence for epistasis between the type 2 diabetes susceptibility loci on chromosomes 1q21-25 and 10q23-26 using two complementary linkage-based approaches. Joint two-locus linkage analysis of 1q and 10q in British pedigrees provided significant evidence for interaction (P

AB - Characterisation of the interactions between susceptibility loci (epistasis) is central to a full understanding of the genetic aetiology and the molecular pathology of complex diseases. We have examined, in British and French pedigrees, evidence for epistasis between the type 2 diabetes susceptibility loci on chromosomes 1q21-25 and 10q23-26 using two complementary linkage-based approaches. Joint two-locus linkage analysis of 1q and 10q in British pedigrees provided significant evidence for interaction (P

U2 - 10.1111/j.1469-1809.2006.00289.x

DO - 10.1111/j.1469-1809.2006.00289.x

M3 - Article

C2 - 17044847

SN - 0003-4800

VL - 70

SP - 726

EP - 737

JO - Annals of Human Genetics

JF - Annals of Human Genetics

ER -

Epistasis Between Type 2 Diabetes Susceptibility Loci on Chromosomes 1q21-25 and 10q23-26 in Northern Europeans

Abstract

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