Epistasis Between Type 2 Diabetes Susceptibility Loci on Chromosomes 1q21-25 and 10q23-26 in Northern Europeans

Steve Wiltshire, J.T. Bell, C.J. Groves, C. Dina, A.T. Hattersley, T.M. Frayling, M. Walker, G.A. Hitman, M. Vaxillaire, M. Farrall, P. Froguel, M.I. Mccarthy

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14 Citations (Scopus)

Abstract

Characterisation of the interactions between susceptibility loci (epistasis) is central to a full understanding of the genetic aetiology and the molecular pathology of complex diseases. We have examined, in British and French pedigrees, evidence for epistasis between the type 2 diabetes susceptibility loci on chromosomes 1q21-25 and 10q23-26 using two complementary linkage-based approaches. Joint two-locus linkage analysis of 1q and 10q in British pedigrees provided significant evidence for interaction (P
Original languageEnglish
Pages (from-to)726-737
JournalAnnals of Human Genetics
Volume70
DOIs
Publication statusPublished - 2006

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