Epidemiology of Streptococcus agalactiae in pregnant Western Australian women and characterisation of bacteriophage activity

Research output: ThesisDoctoral Thesis

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Abstract

Streptococcus agalactiae (GBS) is a prominent global perinatal pathogen. Women in Western Australia are screened for GBS during pregnancy and receive prophylactic antibiotics at delivery if colonised. This study was the first to characterise GBS in this population and provided detailed clinical and epidemiological data. This resulted in the development of a novel diagnostic assay and elucidated prevalent serotypes and risk factors; crucial data which will inform selection of future GBS vaccine candidates. The project also resulted in the discovery of novel GBS bacteriophages with anti-bacterial activity against -70% of clinical GBS isolates, presenting a promising alternative to antibiotic prophylaxis.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Thesis sponsors
Award date30 Mar 2019
DOIs
Publication statusUnpublished - 2019

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