Epidemiology of Moraxella catarrhalis in the upper airway of children from the Kalgoorlie-Boulder community

Nevada Pingault

Research output: ThesisDoctoral Thesis

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Abstract

[Truncated abstract] Otitis media (OM), also known as middle ear infection, is a disease commonly seen in childhood. While numerous complications and sequelae can result from this disease, the most common is conductive hearing loss. OM is a multifactorial disease, with more than one risk factor identified in most children. Indigenous populations worldwide have a higher burden of disease for OM, and this is also true of the Australian Aboriginal population. Moraxella catarrhalis is the third most common bacterial pathogen in OM after Streptococcus pneumoniae and Haemophilus influenzae, and accounts for approximately 15% of infections. The Kalgoorlie Otitis Media Research Project (KOMRP) was a longitudinal cohort study aimed to investigate the burden of OM in a group of Aboriginal and non-Aboriginal children from a semi-arid town in Western Australia. Children enrolled in the study were examined up to seven times over a 2-year period. M. catarrhalis isolated from study participants provided an opportunity to examine the epidemiology of this organism in a large, unique cohort. The overall aim of this project was to investigate M. catarrhalis isolated from children enrolled in the KOMRP. Specific objectives of the project were to determine: 1) whether colonising strains of M. catarrhalis changed in the study population and within individual children over time; 2) whether particular strains of M. catarrhalis were associated with OM; 3) whether particular M. catarrhalis genotypes were only found in either the Aboriginal or non-Aboriginal population; 4) whether children simultaneously carried multiple strains of M. catarrhalis; and 5) the level of antimicrobial resistance in the M. catarrhalis strains isolated. M. catarrhalis isolates from 50 Aboriginal and 50 non-Aboriginal children enrolled in the KOMRP were selected for investigation.
Original languageEnglish
QualificationDoctor of Philosophy
Publication statusUnpublished - 2010

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