Epidemiology of Clostridium difficile infection in the Asia-Pacific region

    Research output: ThesisDoctoral Thesis

    836 Downloads (Pure)

    Abstract

    Clostridium difficile infection (CDI) is a primary cause of hospital- and community-associated diarrhoea, generally following antimicrobial exposure. Since 2000, emerging C. difficile strains have caused CDI epidemics with high morbidity and mortality in Europe, North America and Australia. This thesis investigated CDI in Asia-Pacific countries, a region not well-studied previously. The population could be at high risk of CDI due to increasing age and poorly regulated antimicrobial use. Carriage of C. difficile was common but CDI was less severe among Asian patients than elsewhere, most likely due to circulation of many non-toxigenic strains of C. difficile in the region.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Supervisors/Advisors
    • Riley, Thomas, Supervisor
    • Chang, Barbara, Supervisor
    Award date16 Nov 2017
    Publication statusUnpublished - 2016

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