Epidemiology, evolution and clinical impact of Clostridioides difficile ribotype 017 in Thailand

Korakrit Imwattana

doi:10.26182/cpde-fc30

Epidemiology, evolution and clinical impact of Clostridioides difficile ribotype 017 in Thailand

Korakrit Imwattana

School of Biomedical Sciences

Research output: Thesis › Doctoral Thesis

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Abstract

Clostridioides difficileribotype (RT) 017 ranks among the most successful strains of C. difficile in the world, best known for having a high prevalence of antimicrobial resistance. Despite causing global outbreaks since 1995, little is known about C. difficile RT017, especially its origins and clinical impact. This thesis focuses on C. difficile RT017 in Thailand, in Southeast Asia, a region from where the strain likely originated. It explores how C. difficile RT017 spread to other parts of the world, and identifies factors behind the spread. Finally, the clinical impact of C. difficile RT017 compared to other common RTs was determined.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Riley, Thomas, Supervisor Knight, Dan, Supervisor Chang, Barbara, Supervisor Kiratisin, Pattarachai, Supervisor, External person
Award date	12 Nov 2021
DOIs	https://doi.org/10.26182/cpde-fc30
Publication status	Unpublished - 2021

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THESIS - DOCTOR OF PHILOSOPHY - IMWATTANA Korakrit - 2021
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Cite this

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AB - Clostridioides difficileribotype (RT) 017 ranks among the most successful strains of C. difficile in the world, best known for having a high prevalence of antimicrobial resistance. Despite causing global outbreaks since 1995, little is known about C. difficile RT017, especially its origins and clinical impact. This thesis focuses on C. difficile RT017 in Thailand, in Southeast Asia, a region from where the strain likely originated. It explores how C. difficile RT017 spread to other parts of the world, and identifies factors behind the spread. Finally, the clinical impact of C. difficile RT017 compared to other common RTs was determined.

KW - Clostridioides difficile

KW - epidemiology

KW - genomics

KW - Thailand

KW - antimicrobial resistance

U2 - 10.26182/cpde-fc30

DO - 10.26182/cpde-fc30

M3 - Doctoral Thesis

ER -

Epidemiology, evolution and clinical impact of Clostridioides difficile ribotype 017 in Thailand

Abstract

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