Epidemiology and Clinical Features of Heart Failure with Preserved Ejection Fraction

Kanako Teramoto, Tiew-Hwa Katherine Teng, Chanchal Chandramouli, Jasper Tromp, Yasuhiko Sakata, Carolyn Sp Lam

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)


Heart failure (HF) with preserved ejection (HFpEF) constitutes a large and growing proportion of patients with HF around the world, and is now responsible for more than half of all HF cases in ageing societies. While classically described as a condition of elderly, hypertensive women, recent studies suggest heterogeneity in clinical phenotypes involving differential characteristics and pathophysiological mechanisms. Despite a paucity of disease-modifying therapy for HFpEF, an understanding of phenotypic similarities and differences among patients with HFpEF around the world provides the foundation to recognise the clinical condition for early treatment, as well as to identify modifiable risk factors for preventive intervention. This review summarises the epidemiology of HFpEF, its common clinical features and risk factors, as well as differences by age, comorbidities, race/ethnicity and geography.
Original languageEnglish
Article numbere27
JournalCardiac Failure Review
Early online date4 Aug 2022
Publication statusPublished - 2022


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