Epidemiological Associations of Various Substances and Multiple Cannabinoids with Autism in USA

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Abstract

Introduction: Autistic Spectrum Disorder (ASD) is increasing in across USA. Paediatricians and physicians in both Colorado and Australia continue to see high caseloads however this prevalence uptick remains largely unexplained.Since drug use is an obvious potential source of developmental brain damage the present study was undertaken to study drug-ASD associations at state level. Methods: Existing datasets from the US Department of Education Individuals with Disabilities Act, the Substance Abuse and Mental Health Services Administration National Survey of Drug Use and Health, and the Drug Enforcement Agency cannabinoid concentration in seizures were re-analyzed. Results: ASD rates are high and rising fastest in Colorado, Maine, Massachusetts, Oregon, Rhode Island and New Jersey but falling in Oklahoma and Iowa. When the nine highest cannabis use states are grouped together ASD is rising significantly faster there than elsewhere (time:status interaction in quadratic mixed effects model p
Original languageEnglish
Number of pages20
JournalClinical Pediatrics: Open Access
Volume4
Issue number2
Publication statusPublished - 27 May 2019

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Cannabinoids
Autistic Disorder
Pharmaceutical Preparations
Health Services Misuse
Health Services Administration
Accidental Falls
Mental Health Services
Cannabis
Substance-Related Disorders
Seizures
Physicians
Education
Health
Brain

Cite this

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title = "Epidemiological Associations of Various Substances and Multiple Cannabinoids with Autism in USA",
abstract = "Introduction: Autistic Spectrum Disorder (ASD) is increasing in across USA. Paediatricians and physicians in both Colorado and Australia continue to see high caseloads however this prevalence uptick remains largely unexplained.Since drug use is an obvious potential source of developmental brain damage the present study was undertaken to study drug-ASD associations at state level. Methods: Existing datasets from the US Department of Education Individuals with Disabilities Act, the Substance Abuse and Mental Health Services Administration National Survey of Drug Use and Health, and the Drug Enforcement Agency cannabinoid concentration in seizures were re-analyzed. Results: ASD rates are high and rising fastest in Colorado, Maine, Massachusetts, Oregon, Rhode Island and New Jersey but falling in Oklahoma and Iowa. When the nine highest cannabis use states are grouped together ASD is rising significantly faster there than elsewhere (time:status interaction in quadratic mixed effects model p",
keywords = "Cannabis, Opioids, Cannabidiol, Cannabinol, Tetrahydrocannabinol, Autism spectrum disorder",
author = "Stuart Reece and Gary Hulse",
year = "2019",
month = "5",
day = "27",
language = "English",
volume = "4",
journal = "Clinical Pediatrics: Open Access",
issn = "2572-0775",
publisher = "Longdom Publishing",
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TY - JOUR

T1 - Epidemiological Associations of Various Substances and Multiple Cannabinoids with Autism in USA

AU - Reece, Stuart

AU - Hulse, Gary

PY - 2019/5/27

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N2 - Introduction: Autistic Spectrum Disorder (ASD) is increasing in across USA. Paediatricians and physicians in both Colorado and Australia continue to see high caseloads however this prevalence uptick remains largely unexplained.Since drug use is an obvious potential source of developmental brain damage the present study was undertaken to study drug-ASD associations at state level. Methods: Existing datasets from the US Department of Education Individuals with Disabilities Act, the Substance Abuse and Mental Health Services Administration National Survey of Drug Use and Health, and the Drug Enforcement Agency cannabinoid concentration in seizures were re-analyzed. Results: ASD rates are high and rising fastest in Colorado, Maine, Massachusetts, Oregon, Rhode Island and New Jersey but falling in Oklahoma and Iowa. When the nine highest cannabis use states are grouped together ASD is rising significantly faster there than elsewhere (time:status interaction in quadratic mixed effects model p

AB - Introduction: Autistic Spectrum Disorder (ASD) is increasing in across USA. Paediatricians and physicians in both Colorado and Australia continue to see high caseloads however this prevalence uptick remains largely unexplained.Since drug use is an obvious potential source of developmental brain damage the present study was undertaken to study drug-ASD associations at state level. Methods: Existing datasets from the US Department of Education Individuals with Disabilities Act, the Substance Abuse and Mental Health Services Administration National Survey of Drug Use and Health, and the Drug Enforcement Agency cannabinoid concentration in seizures were re-analyzed. Results: ASD rates are high and rising fastest in Colorado, Maine, Massachusetts, Oregon, Rhode Island and New Jersey but falling in Oklahoma and Iowa. When the nine highest cannabis use states are grouped together ASD is rising significantly faster there than elsewhere (time:status interaction in quadratic mixed effects model p

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KW - Opioids

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KW - Cannabinol

KW - Tetrahydrocannabinol

KW - Autism spectrum disorder

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JO - Clinical Pediatrics: Open Access

JF - Clinical Pediatrics: Open Access

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