Epidemiological and mendelian randomization studies of dihydrotestosterone and estradiol and leukocyte telomere length in men

Bu Yeap, Matthew Knuiman, Mark Divitini, J. Hui, G.M. Arscott, D.J. Handelsman, S.V. Mclennan, S.M. Twigg, Brendan McQuillan, Joe Hung, John Beilby

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Abstract

© 2016 by the Endocrine Society. Context: Advancing age is accompanied by an accumulation of ill health and shortening of chromosomal telomeres signifying biological aging. T is metabolized to DHT by 5α-reductase (SRD5A2) and to estradiol (E2) by aromatase (CYP19A1). Telomerase preserves telomeres, and T and E2 regulate telomerase expression and activity in vitro. Objective: The objective of the study was to establish whether circulating T or its metabolites, DHT or E2, and single-nucleotide polymorphisms in SRD5A2 or CYP19A1 associate with leucocyte telomere length (LTL) in men. Participants and Methods: Early-morning serum T, DHT, and E2 were assayed using mass spectrometry, and SRD5A2 and CYP19A1 single-nucleotide polymorphisms and LTL analyzed by PCR in 980 men from the Western Australian Busselton Health Survey who participated in the study. LTL was expressed as the T/S ratio. Results: Men were aged (mean ± SD) 53.7 ± 15.6 years. LTL decreased linearly with age, from the T/S ratio of 1.89 ± 0.41 at younger than 30 years to 1.50 ± 0.49 at 70 to younger than 80 years (r =-0.225, P
Original languageEnglish
Pages (from-to)1299-1306
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume101
Issue number4
DOIs
Publication statusPublished - 1 Mar 2016

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