EP797 20 years of ultra radical surgery for ovarian cancer patients in perth western australia, what have we learnt?

Lachlan Baxter, Chloe Ayres, P Cohen, R Kader Ali Mohan, Y Leung

Research output: Contribution to journalArticle

Abstract

Introduction/Background Primary cytoreductive surgery followed by adjuvant taxane- and platinum-based combination chemotherapy are the standard treatments for advanced ovarian cancer in most patient populations. Much has been debated regarding the competing perspectives of the tumour biology versus the value of aggressive surgical resection in ovarian cancer as major survival determinants.Many recent studies have showed significant survival advantages for optimally cytoreduced patients. Secondary to this many gynaecological unites, including out own, has adopted a policy of aggressive cytoreduction, often involving bowel resection.The detraction however from ultra-radical surgery is the associated morbidity of ultra-radical surgery.The aim of this study is to assess radical debulking of ovarian cancer with concomitant rectosigmoid resection, with respect to perioperative complication rates and its impact on survival following surgery in a tertiary unit in Perth Western Australia.Methodology A retrospective review was performed of the case notes of 164 consecutive procedures performed between 2000 and 2017 in a regional cancer centre.Results 11.4% of patients suffered some form of complication during admission. Anastomotic complications were rare, occurring in only 1.5% of patients. Perioperative mortality was 2.6%. Overall mean survival was 45 months. Mean survival and progression free survival were significantly longer in the ultra-radical group.Conclusion Ultra-radical surgery for ovarian cancer ensure optimal cytoreduction and increased median survival time, with low rates of intra operative and post operative morbidity.Disclosure Nothing to disclose.
Original languageEnglish
Pages (from-to)A438
JournalInternational Journal of Gynecologic Cancer
Volume29
Issue numberSuppl 4
DOIs
Publication statusPublished - 1 Nov 2019

Fingerprint

Western Australia
Ovarian Neoplasms
Survival
Morbidity
Disclosure
Combination Drug Therapy
Platinum
Disease-Free Survival
Neoplasms
Mortality
Population

Cite this

@article{edbda50ac2cc4fb1b250be7673db660a,
title = "EP797 20 years of ultra radical surgery for ovarian cancer patients in perth western australia, what have we learnt?",
abstract = "Introduction/Background Primary cytoreductive surgery followed by adjuvant taxane- and platinum-based combination chemotherapy are the standard treatments for advanced ovarian cancer in most patient populations. Much has been debated regarding the competing perspectives of the tumour biology versus the value of aggressive surgical resection in ovarian cancer as major survival determinants.Many recent studies have showed significant survival advantages for optimally cytoreduced patients. Secondary to this many gynaecological unites, including out own, has adopted a policy of aggressive cytoreduction, often involving bowel resection.The detraction however from ultra-radical surgery is the associated morbidity of ultra-radical surgery.The aim of this study is to assess radical debulking of ovarian cancer with concomitant rectosigmoid resection, with respect to perioperative complication rates and its impact on survival following surgery in a tertiary unit in Perth Western Australia.Methodology A retrospective review was performed of the case notes of 164 consecutive procedures performed between 2000 and 2017 in a regional cancer centre.Results 11.4{\%} of patients suffered some form of complication during admission. Anastomotic complications were rare, occurring in only 1.5{\%} of patients. Perioperative mortality was 2.6{\%}. Overall mean survival was 45 months. Mean survival and progression free survival were significantly longer in the ultra-radical group.Conclusion Ultra-radical surgery for ovarian cancer ensure optimal cytoreduction and increased median survival time, with low rates of intra operative and post operative morbidity.Disclosure Nothing to disclose.",
author = "Lachlan Baxter and Chloe Ayres and P Cohen and {Kader Ali Mohan}, R and Y Leung",
year = "2019",
month = "11",
day = "1",
doi = "10.1136/ijgc-2019-ESGO.847",
language = "English",
volume = "29",
pages = "A438",
journal = "International Journal of Gynecologic Cancer",
issn = "1048-891X",
publisher = "BMJ Specialist Journals",
number = "Suppl 4",

}

EP797 20 years of ultra radical surgery for ovarian cancer patients in perth western australia, what have we learnt? / Baxter, Lachlan; Ayres, Chloe; Cohen, P; Kader Ali Mohan, R; Leung, Y.

In: International Journal of Gynecologic Cancer, Vol. 29, No. Suppl 4, 01.11.2019, p. A438.

Research output: Contribution to journalArticle

TY - JOUR

T1 - EP797 20 years of ultra radical surgery for ovarian cancer patients in perth western australia, what have we learnt?

AU - Baxter, Lachlan

AU - Ayres, Chloe

AU - Cohen, P

AU - Kader Ali Mohan, R

AU - Leung, Y

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Introduction/Background Primary cytoreductive surgery followed by adjuvant taxane- and platinum-based combination chemotherapy are the standard treatments for advanced ovarian cancer in most patient populations. Much has been debated regarding the competing perspectives of the tumour biology versus the value of aggressive surgical resection in ovarian cancer as major survival determinants.Many recent studies have showed significant survival advantages for optimally cytoreduced patients. Secondary to this many gynaecological unites, including out own, has adopted a policy of aggressive cytoreduction, often involving bowel resection.The detraction however from ultra-radical surgery is the associated morbidity of ultra-radical surgery.The aim of this study is to assess radical debulking of ovarian cancer with concomitant rectosigmoid resection, with respect to perioperative complication rates and its impact on survival following surgery in a tertiary unit in Perth Western Australia.Methodology A retrospective review was performed of the case notes of 164 consecutive procedures performed between 2000 and 2017 in a regional cancer centre.Results 11.4% of patients suffered some form of complication during admission. Anastomotic complications were rare, occurring in only 1.5% of patients. Perioperative mortality was 2.6%. Overall mean survival was 45 months. Mean survival and progression free survival were significantly longer in the ultra-radical group.Conclusion Ultra-radical surgery for ovarian cancer ensure optimal cytoreduction and increased median survival time, with low rates of intra operative and post operative morbidity.Disclosure Nothing to disclose.

AB - Introduction/Background Primary cytoreductive surgery followed by adjuvant taxane- and platinum-based combination chemotherapy are the standard treatments for advanced ovarian cancer in most patient populations. Much has been debated regarding the competing perspectives of the tumour biology versus the value of aggressive surgical resection in ovarian cancer as major survival determinants.Many recent studies have showed significant survival advantages for optimally cytoreduced patients. Secondary to this many gynaecological unites, including out own, has adopted a policy of aggressive cytoreduction, often involving bowel resection.The detraction however from ultra-radical surgery is the associated morbidity of ultra-radical surgery.The aim of this study is to assess radical debulking of ovarian cancer with concomitant rectosigmoid resection, with respect to perioperative complication rates and its impact on survival following surgery in a tertiary unit in Perth Western Australia.Methodology A retrospective review was performed of the case notes of 164 consecutive procedures performed between 2000 and 2017 in a regional cancer centre.Results 11.4% of patients suffered some form of complication during admission. Anastomotic complications were rare, occurring in only 1.5% of patients. Perioperative mortality was 2.6%. Overall mean survival was 45 months. Mean survival and progression free survival were significantly longer in the ultra-radical group.Conclusion Ultra-radical surgery for ovarian cancer ensure optimal cytoreduction and increased median survival time, with low rates of intra operative and post operative morbidity.Disclosure Nothing to disclose.

U2 - 10.1136/ijgc-2019-ESGO.847

DO - 10.1136/ijgc-2019-ESGO.847

M3 - Article

VL - 29

SP - A438

JO - International Journal of Gynecologic Cancer

JF - International Journal of Gynecologic Cancer

SN - 1048-891X

IS - Suppl 4

ER -