Enzymatic synthesis of peptides on a solid support

Rose Haddoub, Martin Dauner, Fiona A. Stefanowicz, Valeria Barattini, Nicolas Laurent, Sabine L. Flitsch

Research output: Contribution to journalArticlepeer-review

15 Citations (Web of Science)


We have previously shown that dipeptides can be synthesised in high yields from amino acids using protease catalysis in aqueous media, if the amino component is immobilised on porous PEGA resin (a copolymer of polyethylene glycol and polyacrylamide). Here we explore the scope of this methodology for using protected and glycosylated amino acids as well as the synthesis of longer peptides on resin and show that such a method can also be applied on non-porous surfaces, in particular on gold.

Original languageEnglish
Pages (from-to)665-670
Number of pages6
JournalOrganic & Biomolecular Chemistry
Issue number4
Publication statusPublished - 2009
Externally publishedYes


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