Environmental enrichment attenuates traumatic brain injury: Induced neuronal hyperexcitability in supragranular layers of sensory cortex

D.S. S. Alwis, E.B. B. Yan, Vicky Johnstone, S. Carron, S. Hellewell, M.C. C. Morganti-Kossmann, R. Rajan

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

© Mary Ann Liebert, Inc. 2016.We have previously demonstrated that traumatic brain injury (TBI) induces significant long-term neuronal hyperexcitability in supragranular layers of sensory cortex, coupled with persistent sensory deficits. Hence, we aimed to investigate whether brain plasticity induced by environmental enrichment (EE) could attenuate abnormal neuronal and sensory function post-TBI. TBI (n = 22) and sham control (n = 21) animals were randomly assigned housing in either single or enriched conditions for 7-9 weeks. Then, in terminal experiments, extracellular recordings were obtained from barrel cortex neurons in response to whisker motion, including those mimicking motion in awake animals undertaking different tasks. Long-term EE exposure (6 weeks) attenuated TBI-induced hyperexcitability in layers 2-3, such that neuronal activity in TBI animals exposed to EE was restored to control levels. Little to no EE-induced changes in population neuronal responses occurred in input layer 4 and output layer 5. However, single-cell responses demonstrated EE-induced hypoexcitation in L4 post-TBI. EE was also able to fully ameliorate sensory hypersensitivity post-TBI, although it was not found to improve motor function. Long-term enrichment post-TBI induces changes at both the population and single-cell level in the sensory cortex, where EE may act to restore the excitation/inhibition balance in supragranular cortical layers.
Original languageEnglish
Pages (from-to)1084-1101
Number of pages18
JournalJournal of Neurotrauma
Volume33
Issue number11
DOIs
Publication statusPublished - 2016
Externally publishedYes

Fingerprint

Vibrissae
Traumatic Brain Injury
Environmental Exposure
Population
Hypersensitivity
Neurons
Brain
Inhibition (Psychology)

Cite this

Alwis, D.S. S. ; Yan, E.B. B. ; Johnstone, Vicky ; Carron, S. ; Hellewell, S. ; Morganti-Kossmann, M.C. C. ; Rajan, R. / Environmental enrichment attenuates traumatic brain injury : Induced neuronal hyperexcitability in supragranular layers of sensory cortex. In: Journal of Neurotrauma. 2016 ; Vol. 33, No. 11. pp. 1084-1101.
@article{c56c4a521f04496a99b4125e9024aa6e,
title = "Environmental enrichment attenuates traumatic brain injury: Induced neuronal hyperexcitability in supragranular layers of sensory cortex",
abstract = "{\circledC} Mary Ann Liebert, Inc. 2016.We have previously demonstrated that traumatic brain injury (TBI) induces significant long-term neuronal hyperexcitability in supragranular layers of sensory cortex, coupled with persistent sensory deficits. Hence, we aimed to investigate whether brain plasticity induced by environmental enrichment (EE) could attenuate abnormal neuronal and sensory function post-TBI. TBI (n = 22) and sham control (n = 21) animals were randomly assigned housing in either single or enriched conditions for 7-9 weeks. Then, in terminal experiments, extracellular recordings were obtained from barrel cortex neurons in response to whisker motion, including those mimicking motion in awake animals undertaking different tasks. Long-term EE exposure (6 weeks) attenuated TBI-induced hyperexcitability in layers 2-3, such that neuronal activity in TBI animals exposed to EE was restored to control levels. Little to no EE-induced changes in population neuronal responses occurred in input layer 4 and output layer 5. However, single-cell responses demonstrated EE-induced hypoexcitation in L4 post-TBI. EE was also able to fully ameliorate sensory hypersensitivity post-TBI, although it was not found to improve motor function. Long-term enrichment post-TBI induces changes at both the population and single-cell level in the sensory cortex, where EE may act to restore the excitation/inhibition balance in supragranular cortical layers.",
author = "Alwis, {D.S. S.} and Yan, {E.B. B.} and Vicky Johnstone and S. Carron and S. Hellewell and Morganti-Kossmann, {M.C. C.} and R. Rajan",
year = "2016",
doi = "10.1089/neu.2014.3774",
language = "English",
volume = "33",
pages = "1084--1101",
journal = "Journal of Neurotrauma",
issn = "0897-7151",
publisher = "Mary Ann Liebert Inc",
number = "11",

}

Environmental enrichment attenuates traumatic brain injury : Induced neuronal hyperexcitability in supragranular layers of sensory cortex. / Alwis, D.S. S.; Yan, E.B. B.; Johnstone, Vicky; Carron, S.; Hellewell, S.; Morganti-Kossmann, M.C. C.; Rajan, R.

In: Journal of Neurotrauma, Vol. 33, No. 11, 2016, p. 1084-1101.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Environmental enrichment attenuates traumatic brain injury

T2 - Induced neuronal hyperexcitability in supragranular layers of sensory cortex

AU - Alwis, D.S. S.

AU - Yan, E.B. B.

AU - Johnstone, Vicky

AU - Carron, S.

AU - Hellewell, S.

AU - Morganti-Kossmann, M.C. C.

AU - Rajan, R.

PY - 2016

Y1 - 2016

N2 - © Mary Ann Liebert, Inc. 2016.We have previously demonstrated that traumatic brain injury (TBI) induces significant long-term neuronal hyperexcitability in supragranular layers of sensory cortex, coupled with persistent sensory deficits. Hence, we aimed to investigate whether brain plasticity induced by environmental enrichment (EE) could attenuate abnormal neuronal and sensory function post-TBI. TBI (n = 22) and sham control (n = 21) animals were randomly assigned housing in either single or enriched conditions for 7-9 weeks. Then, in terminal experiments, extracellular recordings were obtained from barrel cortex neurons in response to whisker motion, including those mimicking motion in awake animals undertaking different tasks. Long-term EE exposure (6 weeks) attenuated TBI-induced hyperexcitability in layers 2-3, such that neuronal activity in TBI animals exposed to EE was restored to control levels. Little to no EE-induced changes in population neuronal responses occurred in input layer 4 and output layer 5. However, single-cell responses demonstrated EE-induced hypoexcitation in L4 post-TBI. EE was also able to fully ameliorate sensory hypersensitivity post-TBI, although it was not found to improve motor function. Long-term enrichment post-TBI induces changes at both the population and single-cell level in the sensory cortex, where EE may act to restore the excitation/inhibition balance in supragranular cortical layers.

AB - © Mary Ann Liebert, Inc. 2016.We have previously demonstrated that traumatic brain injury (TBI) induces significant long-term neuronal hyperexcitability in supragranular layers of sensory cortex, coupled with persistent sensory deficits. Hence, we aimed to investigate whether brain plasticity induced by environmental enrichment (EE) could attenuate abnormal neuronal and sensory function post-TBI. TBI (n = 22) and sham control (n = 21) animals were randomly assigned housing in either single or enriched conditions for 7-9 weeks. Then, in terminal experiments, extracellular recordings were obtained from barrel cortex neurons in response to whisker motion, including those mimicking motion in awake animals undertaking different tasks. Long-term EE exposure (6 weeks) attenuated TBI-induced hyperexcitability in layers 2-3, such that neuronal activity in TBI animals exposed to EE was restored to control levels. Little to no EE-induced changes in population neuronal responses occurred in input layer 4 and output layer 5. However, single-cell responses demonstrated EE-induced hypoexcitation in L4 post-TBI. EE was also able to fully ameliorate sensory hypersensitivity post-TBI, although it was not found to improve motor function. Long-term enrichment post-TBI induces changes at both the population and single-cell level in the sensory cortex, where EE may act to restore the excitation/inhibition balance in supragranular cortical layers.

U2 - 10.1089/neu.2014.3774

DO - 10.1089/neu.2014.3774

M3 - Article

VL - 33

SP - 1084

EP - 1101

JO - Journal of Neurotrauma

JF - Journal of Neurotrauma

SN - 0897-7151

IS - 11

ER -