Osteoporosis is an aging-associated degenerative bone disease that occurs via the imbalanced activities of bone resorbing osteoclasts and bone forming osteoblasts, resulting in brittle bones susceptible to fractures. ENU-induced mutant mice were screened for bone phenotypes to identify novel molecules regulating bone homeostasis, leading to the discovery of a mouse line with an S24P mutation in the Bcl-2 gene BH4 domain, exhibiting aging and osteoporosis. The impact of this mutation was investigated ex vivo through analysis of the bone phenotype of the mice and in vitro through analysis of molecular and cellular activities of osteoclasts and osteoblasts from mutant mice.
|Award date||27 Jul 2017|
|Publication status||Unpublished - 2017|