Enterovirus D68 disease and molecular epidemiology in Australia

Avram Levy, J. Roberts, J. Lang, S. Tempone, A. Kesson, A. Dofai, A.J. Daley, B. Thorley, David Speers

    Research output: Contribution to journalArticle

    30 Citations (Scopus)

    Abstract

    © 2015 Elsevier B.V. Background: Enterovirus D68 (EV-D68) has received considerable recent attention as a cause of widespread respiratory illness. Neurological syndromes such as acute flaccid paralysis following EV-D68 infection have also been reported in a small number of cases. Objectives: To summarize the clinical and epidemiological characteristics of laboratory confirmed EV-D68 cases in Australia. Study design: We combined EV-D68 data acquired through laboratory surveillance in Western Australia with cases from national enterovirus surveillance and regional acute flaccid paralysis (AFP) surveillance. Clinical data was obtained for EV-D68 cases and capsid protein sequences were used for phylogenetic analysis. Results: Sporadic cases of EV-D68 were recorded in Australia since 2008, with peaks in activity during 2011 and 2013. EV-D68 was primarily associated with respiratory disease, but was also detected in cerebrospinal fluid of one patient and faeces of two patients presenting with AFP. Conclusions: EV-D68 has been circulating in Western Australia and is likely to have also been present in the wider region for a number of years, causing primarily respiratory disease. Detection of EV-D68 in cerebrospinal fluid of one patient and in faeces of two AFP cases reinforces the association between EV-D68 and neurological disease.
    Original languageEnglish
    Pages (from-to)117-121
    JournalJournal of Clinical Virology
    Volume69
    DOIs
    Publication statusPublished - 2015

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