Enteral branched-chain amino acids increase the specific activity of jejunal glutaminase and reduce jejunal atrophy

Rosalie Mccauley, K.A. Heel, John Hall

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Branched-chain amino acid (BCAA)-enriched nutrient solutions reduce,out atrophy associated with parenteral nutrition. We hypothesized that this effect was mediated by phosphate-dependent glutaminase. Thirty male Wistar rats (300-350g) underwent a standardized surgical procedure and were then randomized into three groups to receive 6 days of ad libitum enteral nutrition. The animals were fed a solution of conventional nutrients, a solution of conventional nutrients enriched with 2.0% BCAA or a solution of conventional parenteral nutrients enriched with 2.5% glutamine. When compared with rats fed conventional nutrients, rats fed BCAA. and glutamine had less jejunal atrophy (P<0.05) and a greater specific activity of phosphate-dependent glutaminase in the jejunum (131%; P<0.05). It is concluded that enteral BCAA reduce atrophy of the jejunum via the generation of glutamine.
Original languageEnglish
Pages (from-to)429-433
JournalJournal of Gastroenterology and Hepatology
Volume12
DOIs
Publication statusPublished - 1997

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