Enhancement of vaccine-specific cellular immunity in infants by pasively acquired maternal antibody

J. Rowe, J.T. Poolman, C. Macaubas, Peter Sly, R. Loh, Patrick Holt

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

The known protective effects of passively acquired maternal antibody on the resistance of newborns to infections have prompted widespread interest in maternal vaccination. However, a range of animal model and human studies indicate potential inhibitory effects of maternal antibody on vaccine-specific humoral responses in infants. In the present study we have examined the relationship between maternally acquired TT-specific IgG present before DTaP vaccination and subsequent TT-specific T-cell memory responses at 12 and 18 months, in a cohort of 118 infants. We demonstrate a strong positive association between TT-specific cellular immunity as evidenced by increased IL-4, IL-5 and IL-13 responses, and maternal TT-specific IgG.
Original languageEnglish
Pages (from-to)3986-3992
JournalVaccine
Volume22
Issue number29-30
DOIs
Publication statusPublished - 2004

Fingerprint

Dive into the research topics of 'Enhancement of vaccine-specific cellular immunity in infants by pasively acquired maternal antibody'. Together they form a unique fingerprint.

Cite this