Enhanced drug metabolism in cigarette smokers

Prue Hart, G. C. Farrell, W. G.E. Cooksley, L. W. Powell

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

The effect of cigarette smoking on salivary antipyrine disappearance rate, and as an index of hepatic drug metabolism, was studied in 42 healthy subjects. Antipyrine half life was significantly shorter in smokers compared with non-smokers. To determine whether this difference was due solely to tobacco consumption eight subjects were restudied two months after they stopped smoking. The mean antipyrine disappearance rate in this group increased by 23% in contrast to that of a control group, which did not alter. Cigarette smoking contributes to the considerable variation in interindividual rates of drug metabolism.

Original languageEnglish
Pages (from-to)147-149
Number of pages3
JournalBritish Medical Journal
Volume2
Issue number6028
DOIs
Publication statusPublished - 1 Jan 1976
Externally publishedYes

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Antipyrine
Tobacco Products
Smoking
Pharmaceutical Preparations
Tobacco Use
Half-Life
Healthy Volunteers
Control Groups
Liver

Cite this

Hart, P., Farrell, G. C., Cooksley, W. G. E., & Powell, L. W. (1976). Enhanced drug metabolism in cigarette smokers. British Medical Journal, 2(6028), 147-149. https://doi.org/10.1136/bmj.2.6028.147
Hart, Prue ; Farrell, G. C. ; Cooksley, W. G.E. ; Powell, L. W. / Enhanced drug metabolism in cigarette smokers. In: British Medical Journal. 1976 ; Vol. 2, No. 6028. pp. 147-149.
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Hart, P, Farrell, GC, Cooksley, WGE & Powell, LW 1976, 'Enhanced drug metabolism in cigarette smokers' British Medical Journal, vol. 2, no. 6028, pp. 147-149. https://doi.org/10.1136/bmj.2.6028.147

Enhanced drug metabolism in cigarette smokers. / Hart, Prue; Farrell, G. C.; Cooksley, W. G.E.; Powell, L. W.

In: British Medical Journal, Vol. 2, No. 6028, 01.01.1976, p. 147-149.

Research output: Contribution to journalArticle

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