Endothelin(B) (ET(B)) receptor-activated potentiation of cholinergic nerve-mediated contraction in human bronchus

Lynette Fernandes; Peter Henry; Paul Rigby; Roy Goldie

doi:10.1111/j.1476-5381.1996.tb15617.x

Endothelin(B) (ET(B)) receptor-activated potentiation of cholinergic nerve-mediated contraction in human bronchus

Lynette Fernandes, Peter Henry, Paul Rigby, Roy Goldie

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

In human isolated bronchial preparations, the endothelin(B) (ET(B)) receptor-selective agonist, sarafotoxin S6c (Stx6c; 1 nM) increased nerve-mediated contraction in response to electrical field stimulation (EFS) at 0.5-1 Hz from 19 +/- 4% to 42 +/- 7% (n=9). This effect was blocked in the presence of the ET(B) receptor-selective antagonist, BQ-788 (10 mu M) These data are consistent with findings in some animal species that ET-1 and related peptides have marked neuromodulatory influences on the cholinergic system. Furthermore, they provide additional support for the concept that ET-1 may have a mediator role in bronchial obstruction in asthma.

Original language	English
Pages (from-to)	1873-1874
Journal	British Journal of Pharmacology
Volume	118
DOIs	https://doi.org/10.1111/j.1476-5381.1996.tb15617.x
Publication status	Published - 1996

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title = "Endothelin(B) (ET(B)) receptor-activated potentiation of cholinergic nerve-mediated contraction in human bronchus",

abstract = "In human isolated bronchial preparations, the endothelin(B) (ET(B)) receptor-selective agonist, sarafotoxin S6c (Stx6c; 1 nM) increased nerve-mediated contraction in response to electrical field stimulation (EFS) at 0.5-1 Hz from 19 +/- 4% to 42 +/- 7% (n=9). This effect was blocked in the presence of the ET(B) receptor-selective antagonist, BQ-788 (10 mu M) These data are consistent with findings in some animal species that ET-1 and related peptides have marked neuromodulatory influences on the cholinergic system. Furthermore, they provide additional support for the concept that ET-1 may have a mediator role in bronchial obstruction in asthma.",

author = "Lynette Fernandes and Peter Henry and Paul Rigby and Roy Goldie",

year = "1996",

doi = "10.1111/j.1476-5381.1996.tb15617.x",

language = "English",

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pages = "1873--1874",

journal = "British Journal of Pharmacology",

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T1 - Endothelin(B) (ET(B)) receptor-activated potentiation of cholinergic nerve-mediated contraction in human bronchus

AU - Fernandes, Lynette

AU - Henry, Peter

AU - Rigby, Paul

AU - Goldie, Roy

PY - 1996

Y1 - 1996

N2 - In human isolated bronchial preparations, the endothelin(B) (ET(B)) receptor-selective agonist, sarafotoxin S6c (Stx6c; 1 nM) increased nerve-mediated contraction in response to electrical field stimulation (EFS) at 0.5-1 Hz from 19 +/- 4% to 42 +/- 7% (n=9). This effect was blocked in the presence of the ET(B) receptor-selective antagonist, BQ-788 (10 mu M) These data are consistent with findings in some animal species that ET-1 and related peptides have marked neuromodulatory influences on the cholinergic system. Furthermore, they provide additional support for the concept that ET-1 may have a mediator role in bronchial obstruction in asthma.

AB - In human isolated bronchial preparations, the endothelin(B) (ET(B)) receptor-selective agonist, sarafotoxin S6c (Stx6c; 1 nM) increased nerve-mediated contraction in response to electrical field stimulation (EFS) at 0.5-1 Hz from 19 +/- 4% to 42 +/- 7% (n=9). This effect was blocked in the presence of the ET(B) receptor-selective antagonist, BQ-788 (10 mu M) These data are consistent with findings in some animal species that ET-1 and related peptides have marked neuromodulatory influences on the cholinergic system. Furthermore, they provide additional support for the concept that ET-1 may have a mediator role in bronchial obstruction in asthma.

U2 - 10.1111/j.1476-5381.1996.tb15617.x

DO - 10.1111/j.1476-5381.1996.tb15617.x

M3 - Article

VL - 118

SP - 1873

EP - 1874

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

ER -

Endothelin(B) (ET(B)) receptor-activated potentiation of cholinergic nerve-mediated contraction in human bronchus

Abstract

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