Endothelin(B) (ET(B)) receptor-activated potentiation of cholinergic nerve-mediated contraction in human bronchus

Lynette Fernandes, Peter Henry, Paul Rigby, Roy Goldie

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

In human isolated bronchial preparations, the endothelin(B) (ET(B)) receptor-selective agonist, sarafotoxin S6c (Stx6c; 1 nM) increased nerve-mediated contraction in response to electrical field stimulation (EFS) at 0.5-1 Hz from 19 +/- 4% to 42 +/- 7% (n=9). This effect was blocked in the presence of the ET(B) receptor-selective antagonist, BQ-788 (10 mu M) These data are consistent with findings in some animal species that ET-1 and related peptides have marked neuromodulatory influences on the cholinergic system. Furthermore, they provide additional support for the concept that ET-1 may have a mediator role in bronchial obstruction in asthma.
Original languageEnglish
Pages (from-to)1873-1874
JournalBritish Journal of Pharmacology
Volume118
DOIs
Publication statusPublished - 1996

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