TY - JOUR
T1 - Endothelial Progenitor Cells, Angioblasts, and Angiogenesis-Old Terms Reconsidered From a Current Perspective
AU - Kovacic, Jason C.
AU - Moore, John
AU - Herbert, Andrea
AU - Ma, David
AU - Boehm, Manfred
AU - Graham, Robert M.
N1 - Funding Information:
Jason Kovacic and Manfred Boehm are funded by the intramural research program of the NIH-NHLBI.
Funding Information:
The Australian-based investigators' research in this field is supported by funding and/or assistance from the St. Vincent's Clinic Foundation, the RT Hall Estate, the Macquarie Foundation, and the National Health and Medical Research Council (of Australia).
PY - 2008/2
Y1 - 2008/2
N2 - When the term 'angioblast' was initially used, almost a century ago, the cells bearing this name were thought to give rise to plasma, red blood cells and endothelium, with new blood vessels arising from 'within the (cell) bodies of these angioblasts'. More recently, putative circulating 'progenitor endothelial cells', often also referred to as angioblasts, were first described in the adult human a mere decade ago. Therefore, while our understanding of progenitor cell biology and other relevant vascular developmental programs has progressed enormously, key terms such as 'angioblast' and 'angiogenesis' have remained constant. With the recent intense interest in angioblasts and endothelial progenitor cells, and their potential with respect to cardiovascular regenerative medicine, our knowledge of how these and other nonprogenitor cells might contribute to new vessel formation has taken a further leap in understanding. In this review, we focus on the controversial use and definition of these terms based upon our current understanding of vascular biology and progenitor cells.
AB - When the term 'angioblast' was initially used, almost a century ago, the cells bearing this name were thought to give rise to plasma, red blood cells and endothelium, with new blood vessels arising from 'within the (cell) bodies of these angioblasts'. More recently, putative circulating 'progenitor endothelial cells', often also referred to as angioblasts, were first described in the adult human a mere decade ago. Therefore, while our understanding of progenitor cell biology and other relevant vascular developmental programs has progressed enormously, key terms such as 'angioblast' and 'angiogenesis' have remained constant. With the recent intense interest in angioblasts and endothelial progenitor cells, and their potential with respect to cardiovascular regenerative medicine, our knowledge of how these and other nonprogenitor cells might contribute to new vessel formation has taken a further leap in understanding. In this review, we focus on the controversial use and definition of these terms based upon our current understanding of vascular biology and progenitor cells.
UR - http://www.scopus.com/inward/record.url?scp=39549117344&partnerID=8YFLogxK
U2 - 10.1016/j.tcm.2007.12.002
DO - 10.1016/j.tcm.2007.12.002
M3 - Review article
C2 - 18308194
AN - SCOPUS:39549117344
SN - 1050-1738
VL - 18
SP - 45
EP - 51
JO - Trends in Cardiovascular Medicine
JF - Trends in Cardiovascular Medicine
IS - 2
ER -