TY - JOUR
T1 - Endocrine consequences of circadian rhythm disruption in early life
AU - Sorensen, Natasha L.
AU - Maloney, Shane K.
AU - Pillow, Jane J.
AU - Mark, Peter J.
PY - 2020/4
Y1 - 2020/4
N2 - Circadian rhythms, primarily entrained through the light–dark cycle, play significant roles in the endocrine system. Fetal circadian rhythms develop through maternal rhythmic secretion of the hormones, melatonin and cortisol. This feto-maternal connection drives the development of the fetal circadian system until birth, to prepare the newborn for the postnatal environment. Conditions that affect maternal circadian rhythms (i.e. shift work and sleep disorders) can affect fetal circadian rhythmicity development, and thus the development of the offspring endocrine system. Furthermore, infants born preterm are hospitalised in neonatal intensive care units where constant light, loud noise and persistent handling disrupts infant sleep and circadian development. The consequences of circadian disruption include melatonin and glucocorticoid dysregulation, which can impact growth, development and other health outcomes.
AB - Circadian rhythms, primarily entrained through the light–dark cycle, play significant roles in the endocrine system. Fetal circadian rhythms develop through maternal rhythmic secretion of the hormones, melatonin and cortisol. This feto-maternal connection drives the development of the fetal circadian system until birth, to prepare the newborn for the postnatal environment. Conditions that affect maternal circadian rhythms (i.e. shift work and sleep disorders) can affect fetal circadian rhythmicity development, and thus the development of the offspring endocrine system. Furthermore, infants born preterm are hospitalised in neonatal intensive care units where constant light, loud noise and persistent handling disrupts infant sleep and circadian development. The consequences of circadian disruption include melatonin and glucocorticoid dysregulation, which can impact growth, development and other health outcomes.
KW - Circadian disruption
KW - Circadian rhythm
KW - Cortisol
KW - Melatonin
KW - Preterm infant
UR - http://www.scopus.com/inward/record.url?scp=85081621408&partnerID=8YFLogxK
U2 - 10.1016/j.coemr.2020.02.001
DO - 10.1016/j.coemr.2020.02.001
M3 - Review article
AN - SCOPUS:85081621408
VL - 11
SP - 65
EP - 71
JO - Current Opinion in Endocrine and Metabolic Research
JF - Current Opinion in Endocrine and Metabolic Research
SN - 2451-9650
ER -