Elucidating the role of sorting nexins in skeletal homeostasis

Audrey Sue Chan

Research output: ThesisDoctoral Thesis

Abstract

The growth and repair of the skeleton are tightly regulated processes that depend on the ability of cells to respond to local and systemic stimuli through surface receptors. The parathyroid hormone receptor type 1 (PTHR) is a class B G protein-coupled
receptor critical for bone growth, remodelling and mineral ion metabolism. In response to stimulation, PTHR elicits signalling
at the cell surface and from within the endosome following receptor internalisation. Sorting Nexin 27 (SNX.27, the only postsynaptic-95, Dlg-1, Z0-1 (PDZ) domain-containing protein of its family) together with retromer, are required for the endosome-to-PM retrieval and therefore, signal termination of PTHR.
LanguageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Pavlos, Nathan, Supervisor
  • Zheng, Ming, Supervisor
Thesis sponsors
Award date24 Jan 2018
DOIs
StateUnpublished - 2018

Fingerprint

Sorting Nexins
Parathyroid Hormone Receptor Type 1
Homeostasis
Endosomes
Bone Remodeling
Bone Development
G-Protein-Coupled Receptors
Skeleton
Minerals
Ions
Growth

Cite this

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title = "Elucidating the role of sorting nexins in skeletal homeostasis",
abstract = "The growth and repair of the skeleton are tightly regulated processes that depend on the ability of cells to respond to local and systemic stimuli through surface receptors. The parathyroid hormone receptor type 1 (PTHR) is a class B G protein-coupledreceptor critical for bone growth, remodelling and mineral ion metabolism. In response to stimulation, PTHR elicits signallingat the cell surface and from within the endosome following receptor internalisation. Sorting Nexin 27 (SNX.27, the only postsynaptic-95, Dlg-1, Z0-1 (PDZ) domain-containing protein of its family) together with retromer, are required for the endosome-to-PM retrieval and therefore, signal termination of PTHR.",
keywords = "skeletal homeostasis, bone, membrane trafficking, sorting nexins, SNX27, PDZ, parathyroid honnone, parathyroid hormone receptor type 1",
author = "Chan, {Audrey Sue}",
year = "2018",
doi = "10.4225/23/5a7bbdbd24d82",
language = "English",
school = "The University of Western Australia",

}

Chan, AS 2018, 'Elucidating the role of sorting nexins in skeletal homeostasis', Doctor of Philosophy, The University of Western Australia. DOI: 10.4225/23/5a7bbdbd24d82

Elucidating the role of sorting nexins in skeletal homeostasis. / Chan, Audrey Sue.

2018.

Research output: ThesisDoctoral Thesis

TY - THES

T1 - Elucidating the role of sorting nexins in skeletal homeostasis

AU - Chan,Audrey Sue

PY - 2018

Y1 - 2018

N2 - The growth and repair of the skeleton are tightly regulated processes that depend on the ability of cells to respond to local and systemic stimuli through surface receptors. The parathyroid hormone receptor type 1 (PTHR) is a class B G protein-coupledreceptor critical for bone growth, remodelling and mineral ion metabolism. In response to stimulation, PTHR elicits signallingat the cell surface and from within the endosome following receptor internalisation. Sorting Nexin 27 (SNX.27, the only postsynaptic-95, Dlg-1, Z0-1 (PDZ) domain-containing protein of its family) together with retromer, are required for the endosome-to-PM retrieval and therefore, signal termination of PTHR.

AB - The growth and repair of the skeleton are tightly regulated processes that depend on the ability of cells to respond to local and systemic stimuli through surface receptors. The parathyroid hormone receptor type 1 (PTHR) is a class B G protein-coupledreceptor critical for bone growth, remodelling and mineral ion metabolism. In response to stimulation, PTHR elicits signallingat the cell surface and from within the endosome following receptor internalisation. Sorting Nexin 27 (SNX.27, the only postsynaptic-95, Dlg-1, Z0-1 (PDZ) domain-containing protein of its family) together with retromer, are required for the endosome-to-PM retrieval and therefore, signal termination of PTHR.

KW - skeletal homeostasis

KW - bone

KW - membrane trafficking

KW - sorting nexins

KW - SNX27

KW - PDZ

KW - parathyroid honnone

KW - parathyroid hormone receptor type 1

U2 - 10.4225/23/5a7bbdbd24d82

DO - 10.4225/23/5a7bbdbd24d82

M3 - Doctoral Thesis

ER -