Elucidating the Immune Response to Radiotherapy and Treatment Augmentation with Checkpoint Blockade Immunotherapy in Mesothelioma

Wesley Wilson

Research output: ThesisDoctoral Thesis

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Abstract

This study investigated and modulated the immune response to radiotherapy in vivo in a murine model of mesothelioma using checkpoint blockade immunotherapy. Analysis of intratumoural and intralymphatic T cells revealed potential targets for immune modulation to radiotherapy. Monoclonal antibodies targeting each immune checkpoint were used to determine their abiliity to increase the anti-tumour response both locally, and at secondary tumour locations. This work provides the basis for conintued investigation into the effects, timing, and scheduling of radiotherapy. These findings lay the groundwork for establishing clinically relevant protocols surrounding the effects of checkpoint blockade immunotherapy given with radiotherapy in solid tumours.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Nowak, Anna, Supervisor
  • Cook, Alistair, Supervisor
  • Cole, Catherine, Supervisor
Thesis sponsors
Award date17 May 2022
DOIs
Publication statusUnpublished - 2021

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