Elevated Serum Homocysteine Levels Have Differential Gender-Specific Associations with Motor and Cognitive States in Parkinson's Disease

Megan C. Bakeberg; Alexa Jefferson; Maddeson Riley; Michelle Byrnes; Soumya Ghosh; Frank L. Mastaglia; Malcom K. Horne; Sarah McGregor; Rick Stell; Jade Kenna; Sue Walters; Dana Hince; Ryan S. Anderton

doi:10.1155/2019/3124295

Elevated Serum Homocysteine Levels Have Differential Gender-Specific Associations with Motor and Cognitive States in Parkinson's Disease

Megan C. Bakeberg, Alexa Jefferson, Maddeson Riley, Michelle Byrnes, Soumya Ghosh, Frank L. Mastaglia, Malcom K. Horne, Sarah McGregor, Rick Stell, Jade Kenna, Sue Walters, Dana Hince, Ryan S. Anderton

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Background. Studies attempting to elucidate an association between homocysteine and symptom progression in Parkinson's disease (PD) have had largely discrepant findings. This study aimed to investigate elevated serum homocysteine levels and symptom progression in a cohort of PD patients. Methods. Serum homocysteine, folate, and vitamin B12 levels were measured in 205 people with PD and 78 age-matched healthy controls. People with Parkinson's disease underwent a battery of clinical assessments to evaluate symptom severity, including motor (MDS-UPDRS) and cognitive (ACE-R) assessments. Multivariate generalised linear models were created, controlling for confounding variables, and were used to determine whether serum markers are associated with various symptom outcome measures. Results. People with Parkinson's disease displayed significantly elevated homocysteine levels (p

Original language	English
Article number	3124295
Number of pages	8
Journal	Parkinson's Disease
Volume	2019
DOIs	https://doi.org/10.1155/2019/3124295
Publication status	Published - 2019

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Bakeberg, M. C., Jefferson, A., Riley, M., Byrnes, M., Ghosh, S., Mastaglia, F. L., Horne, M. K., McGregor, S., Stell, R., Kenna, J., Walters, S., Hince, D., & Anderton, R. S. (2019). Elevated Serum Homocysteine Levels Have Differential Gender-Specific Associations with Motor and Cognitive States in Parkinson's Disease. Parkinson's Disease, 2019, Article 3124295. https://doi.org/10.1155/2019/3124295

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title = "Elevated Serum Homocysteine Levels Have Differential Gender-Specific Associations with Motor and Cognitive States in Parkinson's Disease",

abstract = "Background. Studies attempting to elucidate an association between homocysteine and symptom progression in Parkinson's disease (PD) have had largely discrepant findings. This study aimed to investigate elevated serum homocysteine levels and symptom progression in a cohort of PD patients. Methods. Serum homocysteine, folate, and vitamin B12 levels were measured in 205 people with PD and 78 age-matched healthy controls. People with Parkinson's disease underwent a battery of clinical assessments to evaluate symptom severity, including motor (MDS-UPDRS) and cognitive (ACE-R) assessments. Multivariate generalised linear models were created, controlling for confounding variables, and were used to determine whether serum markers are associated with various symptom outcome measures. Results. People with Parkinson's disease displayed significantly elevated homocysteine levels (p",

keywords = "INDEPENDENT RISK-FACTOR, PLASMA HOMOCYSTEINE, HYPERHOMOCYSTEINEMIA, FOLATE, LEVODOPA, VITAMIN-B12, DEMENTIA, DETERMINANTS, POLYMORPHISM, METABOLISM",

author = "Bakeberg, {Megan C.} and Alexa Jefferson and Maddeson Riley and Michelle Byrnes and Soumya Ghosh and Mastaglia, {Frank L.} and Horne, {Malcom K.} and Sarah McGregor and Rick Stell and Jade Kenna and Sue Walters and Dana Hince and Anderton, {Ryan S.}",

year = "2019",

doi = "10.1155/2019/3124295",

language = "English",

volume = "2019",

journal = "Parkinson's Disease",

issn = "2090-8083",

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Bakeberg, MC, Jefferson, A, Riley, M, Byrnes, M, Ghosh, S, Mastaglia, FL, Horne, MK, McGregor, S, Stell, R, Kenna, J, Walters, S, Hince, D & Anderton, RS 2019, 'Elevated Serum Homocysteine Levels Have Differential Gender-Specific Associations with Motor and Cognitive States in Parkinson's Disease', Parkinson's Disease, vol. 2019, 3124295. https://doi.org/10.1155/2019/3124295

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T1 - Elevated Serum Homocysteine Levels Have Differential Gender-Specific Associations with Motor and Cognitive States in Parkinson's Disease

AU - Bakeberg, Megan C.

AU - Jefferson, Alexa

AU - Riley, Maddeson

AU - Byrnes, Michelle

AU - Ghosh, Soumya

AU - Mastaglia, Frank L.

AU - Horne, Malcom K.

AU - McGregor, Sarah

AU - Stell, Rick

AU - Kenna, Jade

AU - Walters, Sue

AU - Hince, Dana

AU - Anderton, Ryan S.

PY - 2019

Y1 - 2019

N2 - Background. Studies attempting to elucidate an association between homocysteine and symptom progression in Parkinson's disease (PD) have had largely discrepant findings. This study aimed to investigate elevated serum homocysteine levels and symptom progression in a cohort of PD patients. Methods. Serum homocysteine, folate, and vitamin B12 levels were measured in 205 people with PD and 78 age-matched healthy controls. People with Parkinson's disease underwent a battery of clinical assessments to evaluate symptom severity, including motor (MDS-UPDRS) and cognitive (ACE-R) assessments. Multivariate generalised linear models were created, controlling for confounding variables, and were used to determine whether serum markers are associated with various symptom outcome measures. Results. People with Parkinson's disease displayed significantly elevated homocysteine levels (p

AB - Background. Studies attempting to elucidate an association between homocysteine and symptom progression in Parkinson's disease (PD) have had largely discrepant findings. This study aimed to investigate elevated serum homocysteine levels and symptom progression in a cohort of PD patients. Methods. Serum homocysteine, folate, and vitamin B12 levels were measured in 205 people with PD and 78 age-matched healthy controls. People with Parkinson's disease underwent a battery of clinical assessments to evaluate symptom severity, including motor (MDS-UPDRS) and cognitive (ACE-R) assessments. Multivariate generalised linear models were created, controlling for confounding variables, and were used to determine whether serum markers are associated with various symptom outcome measures. Results. People with Parkinson's disease displayed significantly elevated homocysteine levels (p

KW - INDEPENDENT RISK-FACTOR

KW - PLASMA HOMOCYSTEINE

KW - HYPERHOMOCYSTEINEMIA

KW - FOLATE

KW - LEVODOPA

KW - VITAMIN-B12

KW - DEMENTIA

KW - DETERMINANTS

KW - POLYMORPHISM

KW - METABOLISM

U2 - 10.1155/2019/3124295

DO - 10.1155/2019/3124295

M3 - Article

C2 - 31275543

SN - 2090-8083

VL - 2019

JO - Parkinson's Disease

JF - Parkinson's Disease

M1 - 3124295

ER -

Elevated Serum Homocysteine Levels Have Differential Gender-Specific Associations with Motor and Cognitive States in Parkinson's Disease

Abstract

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