Elevated osteoprotegerin predicts declining renal function in elderly women: A 10-year prospective cohort study

Joshua Lewis, Wai Lim, Kun Zhu, G. Wong, S.S. Dhaliwal, E. Lim, T. Ueland, J. Bollerslev, Richard Prince

    Research output: Contribution to journalArticle

    15 Citations (Scopus)
    195 Downloads (Pure)

    Abstract

    Background: Elevated osteoprotegerin (OPG) levels are inversely correlated with creatinine clearance and end-stage renal disease in patients with diabetes, however its role in predicting decline in renal function and progression to a more advanced stage disease in the elderly general population is unknown.

    Methods: This was a prospective cohort study of 1,157 elderly women with serum OPG measured in 1998 and renal function estimated using serum creatinine and cystatin C-based estimated glomerular filtration rate (eGFR) at 5-yearly intervals. The primary objective of the study was to determine the relationship of circulating OPG levels with 5- and 10-year renal decline.

    Results: At baseline, participants with elevated OPG above the median (≥2.2 ng/ml) had a 5.0% lower CKD-EPI-creatinine and cystatin C eGFR compared to participants with lower OPG levels. In multivariable-adjusted linear regression models, elevated OPG levels at baseline were associated with greater 5- and 10-year decline in CKD-EPI-creatinine and cystatin C eGFR (-0.105, p = 0.002 and -0.104, p = 0.010, respectively). Elevated OPG at baseline was associated with increased 5- and 10-year risk of rapid renal decline (OR 2.13, 95% CI 1.33-3.43, p = 0.002 and OR 4.10, 95% CI 1.49-11.27, p = 0.006, respectively) and renal disease hospitalizations or deaths (HR 1.99, 95% CI 1.31-3.03, p = 0.001) after adjusting for known risk factors. Conclusion: Elevated OPG levels are associated with long-term renal dysfunction and may be provide a useful biomarker to predict the trajectory of renal decline in older women. © 2014 S. Karger AG, Basel.
    Original languageEnglish
    Pages (from-to)66-74
    JournalAmerican Journal of Nephrology
    Volume39
    Issue number1
    Early online date21 Jan 2014
    DOIs
    Publication statusPublished - Feb 2014

    Fingerprint

    Osteoprotegerin
    antineoplaston A10
    Cohort Studies
    Prospective Studies
    Kidney
    Cystatin C
    Creatinine
    Glomerular Filtration Rate
    Linear Models
    Serum
    Chronic Kidney Failure
    Hospitalization
    Biomarkers

    Cite this

    @article{f13acb2dabac46238695a689b4243f56,
    title = "Elevated osteoprotegerin predicts declining renal function in elderly women: A 10-year prospective cohort study",
    abstract = "Background: Elevated osteoprotegerin (OPG) levels are inversely correlated with creatinine clearance and end-stage renal disease in patients with diabetes, however its role in predicting decline in renal function and progression to a more advanced stage disease in the elderly general population is unknown. Methods: This was a prospective cohort study of 1,157 elderly women with serum OPG measured in 1998 and renal function estimated using serum creatinine and cystatin C-based estimated glomerular filtration rate (eGFR) at 5-yearly intervals. The primary objective of the study was to determine the relationship of circulating OPG levels with 5- and 10-year renal decline. Results: At baseline, participants with elevated OPG above the median (≥2.2 ng/ml) had a 5.0{\%} lower CKD-EPI-creatinine and cystatin C eGFR compared to participants with lower OPG levels. In multivariable-adjusted linear regression models, elevated OPG levels at baseline were associated with greater 5- and 10-year decline in CKD-EPI-creatinine and cystatin C eGFR (-0.105, p = 0.002 and -0.104, p = 0.010, respectively). Elevated OPG at baseline was associated with increased 5- and 10-year risk of rapid renal decline (OR 2.13, 95{\%} CI 1.33-3.43, p = 0.002 and OR 4.10, 95{\%} CI 1.49-11.27, p = 0.006, respectively) and renal disease hospitalizations or deaths (HR 1.99, 95{\%} CI 1.31-3.03, p = 0.001) after adjusting for known risk factors. Conclusion: Elevated OPG levels are associated with long-term renal dysfunction and may be provide a useful biomarker to predict the trajectory of renal decline in older women. {\circledC} 2014 S. Karger AG, Basel.",
    author = "Joshua Lewis and Wai Lim and Kun Zhu and G. Wong and S.S. Dhaliwal and E. Lim and T. Ueland and J. Bollerslev and Richard Prince",
    year = "2014",
    month = "2",
    doi = "10.1159/000357787",
    language = "English",
    volume = "39",
    pages = "66--74",
    journal = "American Journal of Nephrology",
    issn = "0250-8095",
    publisher = "S Karger AG",
    number = "1",

    }

    Elevated osteoprotegerin predicts declining renal function in elderly women: A 10-year prospective cohort study. / Lewis, Joshua; Lim, Wai; Zhu, Kun; Wong, G.; Dhaliwal, S.S.; Lim, E.; Ueland, T.; Bollerslev, J.; Prince, Richard.

    In: American Journal of Nephrology, Vol. 39, No. 1, 02.2014, p. 66-74.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Elevated osteoprotegerin predicts declining renal function in elderly women: A 10-year prospective cohort study

    AU - Lewis, Joshua

    AU - Lim, Wai

    AU - Zhu, Kun

    AU - Wong, G.

    AU - Dhaliwal, S.S.

    AU - Lim, E.

    AU - Ueland, T.

    AU - Bollerslev, J.

    AU - Prince, Richard

    PY - 2014/2

    Y1 - 2014/2

    N2 - Background: Elevated osteoprotegerin (OPG) levels are inversely correlated with creatinine clearance and end-stage renal disease in patients with diabetes, however its role in predicting decline in renal function and progression to a more advanced stage disease in the elderly general population is unknown. Methods: This was a prospective cohort study of 1,157 elderly women with serum OPG measured in 1998 and renal function estimated using serum creatinine and cystatin C-based estimated glomerular filtration rate (eGFR) at 5-yearly intervals. The primary objective of the study was to determine the relationship of circulating OPG levels with 5- and 10-year renal decline. Results: At baseline, participants with elevated OPG above the median (≥2.2 ng/ml) had a 5.0% lower CKD-EPI-creatinine and cystatin C eGFR compared to participants with lower OPG levels. In multivariable-adjusted linear regression models, elevated OPG levels at baseline were associated with greater 5- and 10-year decline in CKD-EPI-creatinine and cystatin C eGFR (-0.105, p = 0.002 and -0.104, p = 0.010, respectively). Elevated OPG at baseline was associated with increased 5- and 10-year risk of rapid renal decline (OR 2.13, 95% CI 1.33-3.43, p = 0.002 and OR 4.10, 95% CI 1.49-11.27, p = 0.006, respectively) and renal disease hospitalizations or deaths (HR 1.99, 95% CI 1.31-3.03, p = 0.001) after adjusting for known risk factors. Conclusion: Elevated OPG levels are associated with long-term renal dysfunction and may be provide a useful biomarker to predict the trajectory of renal decline in older women. © 2014 S. Karger AG, Basel.

    AB - Background: Elevated osteoprotegerin (OPG) levels are inversely correlated with creatinine clearance and end-stage renal disease in patients with diabetes, however its role in predicting decline in renal function and progression to a more advanced stage disease in the elderly general population is unknown. Methods: This was a prospective cohort study of 1,157 elderly women with serum OPG measured in 1998 and renal function estimated using serum creatinine and cystatin C-based estimated glomerular filtration rate (eGFR) at 5-yearly intervals. The primary objective of the study was to determine the relationship of circulating OPG levels with 5- and 10-year renal decline. Results: At baseline, participants with elevated OPG above the median (≥2.2 ng/ml) had a 5.0% lower CKD-EPI-creatinine and cystatin C eGFR compared to participants with lower OPG levels. In multivariable-adjusted linear regression models, elevated OPG levels at baseline were associated with greater 5- and 10-year decline in CKD-EPI-creatinine and cystatin C eGFR (-0.105, p = 0.002 and -0.104, p = 0.010, respectively). Elevated OPG at baseline was associated with increased 5- and 10-year risk of rapid renal decline (OR 2.13, 95% CI 1.33-3.43, p = 0.002 and OR 4.10, 95% CI 1.49-11.27, p = 0.006, respectively) and renal disease hospitalizations or deaths (HR 1.99, 95% CI 1.31-3.03, p = 0.001) after adjusting for known risk factors. Conclusion: Elevated OPG levels are associated with long-term renal dysfunction and may be provide a useful biomarker to predict the trajectory of renal decline in older women. © 2014 S. Karger AG, Basel.

    U2 - 10.1159/000357787

    DO - 10.1159/000357787

    M3 - Article

    VL - 39

    SP - 66

    EP - 74

    JO - American Journal of Nephrology

    JF - American Journal of Nephrology

    SN - 0250-8095

    IS - 1

    ER -