Elevated KiSS-1 expression in the arcuate nucleus prior to the cyclic preovulatory gonadotrophin-releasing hormone/lutenising hormone surge in the ewe suggests a stimulatory role for kisspeptin in oestrogen-positive feedback

K. M. Estrada; C. M. Clay; S. Pompolo; Jeremy Smith; Iain J. Clarke

doi:10.1111/j.1365-2826.2006.01485.x

Elevated KiSS-1 expression in the arcuate nucleus prior to the cyclic preovulatory gonadotrophin-releasing hormone/lutenising hormone surge in the ewe suggests a stimulatory role for kisspeptin in oestrogen-positive feedback

K. M. Estrada, C. M. Clay, S. Pompolo, Jeremy Smith, Iain J. Clarke

Research output: Contribution to journal › Article › peer-review

177 Citations (Scopus)

Abstract

Kisspeptins are encoded by the gene KiSS-1 and regulate gonadotrophin-releasing hormone (GnRH) and gonadotrophin secretion in various species, including humans. Here, we quantify gene expression of KiSS-1 in the arcuate nucleus (ARC) across the ovine oestrous cycle and demonstrate an increase in the caudal division of the ARC during the preovulatory period. These data strongly suggest that kisspeptins are involved in the generation of the preovulatory GnRH and luteinising hormone surge.

Original language	English
Pages (from-to)	806-809
Number of pages	4
Journal	Journal of Neuroendocrinology
Volume	18
Issue number	10
DOIs	https://doi.org/10.1111/j.1365-2826.2006.01485.x
Publication status	Published - Oct 2006
Externally published	Yes

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Estrada, K. M., Clay, C. M., Pompolo, S., Smith, J., & Clarke, I. J. (2006). Elevated KiSS-1 expression in the arcuate nucleus prior to the cyclic preovulatory gonadotrophin-releasing hormone/lutenising hormone surge in the ewe suggests a stimulatory role for kisspeptin in oestrogen-positive feedback. Journal of Neuroendocrinology, 18(10), 806-809. https://doi.org/10.1111/j.1365-2826.2006.01485.x

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title = "Elevated KiSS-1 expression in the arcuate nucleus prior to the cyclic preovulatory gonadotrophin-releasing hormone/lutenising hormone surge in the ewe suggests a stimulatory role for kisspeptin in oestrogen-positive feedback",

abstract = "Kisspeptins are encoded by the gene KiSS-1 and regulate gonadotrophin-releasing hormone (GnRH) and gonadotrophin secretion in various species, including humans. Here, we quantify gene expression of KiSS-1 in the arcuate nucleus (ARC) across the ovine oestrous cycle and demonstrate an increase in the caudal division of the ARC during the preovulatory period. These data strongly suggest that kisspeptins are involved in the generation of the preovulatory GnRH and luteinising hormone surge.",

keywords = "Hypothalamus, Oestrogen receptor, Oestrous cycle",

author = "Estrada, {K. M.} and Clay, {C. M.} and S. Pompolo and Jeremy Smith and Clarke, {Iain J.}",

year = "2006",

month = oct,

doi = "10.1111/j.1365-2826.2006.01485.x",

language = "English",

volume = "18",

pages = "806--809",

journal = "Journal of Neuroendocrinology",

issn = "0953-8194",

publisher = "John Wiley & Sons",

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}

Estrada, KM, Clay, CM, Pompolo, S, Smith, J & Clarke, IJ 2006, 'Elevated KiSS-1 expression in the arcuate nucleus prior to the cyclic preovulatory gonadotrophin-releasing hormone/lutenising hormone surge in the ewe suggests a stimulatory role for kisspeptin in oestrogen-positive feedback', Journal of Neuroendocrinology, vol. 18, no. 10, pp. 806-809. https://doi.org/10.1111/j.1365-2826.2006.01485.x

Elevated KiSS-1 expression in the arcuate nucleus prior to the cyclic preovulatory gonadotrophin-releasing hormone/lutenising hormone surge in the ewe suggests a stimulatory role for kisspeptin in oestrogen-positive feedback. / Estrada, K. M.; Clay, C. M.; Pompolo, S. et al.
In: Journal of Neuroendocrinology, Vol. 18, No. 10, 10.2006, p. 806-809.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Elevated KiSS-1 expression in the arcuate nucleus prior to the cyclic preovulatory gonadotrophin-releasing hormone/lutenising hormone surge in the ewe suggests a stimulatory role for kisspeptin in oestrogen-positive feedback

AU - Estrada, K. M.

AU - Clay, C. M.

AU - Pompolo, S.

AU - Smith, Jeremy

AU - Clarke, Iain J.

PY - 2006/10

Y1 - 2006/10

N2 - Kisspeptins are encoded by the gene KiSS-1 and regulate gonadotrophin-releasing hormone (GnRH) and gonadotrophin secretion in various species, including humans. Here, we quantify gene expression of KiSS-1 in the arcuate nucleus (ARC) across the ovine oestrous cycle and demonstrate an increase in the caudal division of the ARC during the preovulatory period. These data strongly suggest that kisspeptins are involved in the generation of the preovulatory GnRH and luteinising hormone surge.

AB - Kisspeptins are encoded by the gene KiSS-1 and regulate gonadotrophin-releasing hormone (GnRH) and gonadotrophin secretion in various species, including humans. Here, we quantify gene expression of KiSS-1 in the arcuate nucleus (ARC) across the ovine oestrous cycle and demonstrate an increase in the caudal division of the ARC during the preovulatory period. These data strongly suggest that kisspeptins are involved in the generation of the preovulatory GnRH and luteinising hormone surge.

KW - Hypothalamus

KW - Oestrogen receptor

KW - Oestrous cycle

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DO - 10.1111/j.1365-2826.2006.01485.x

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AN - SCOPUS:33748414042

SN - 0953-8194

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SP - 806

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Estrada KM, Clay CM, Pompolo S, Smith J, Clarke IJ. Elevated KiSS-1 expression in the arcuate nucleus prior to the cyclic preovulatory gonadotrophin-releasing hormone/lutenising hormone surge in the ewe suggests a stimulatory role for kisspeptin in oestrogen-positive feedback. Journal of Neuroendocrinology. 2006 Oct;18(10):806-809. doi: 10.1111/j.1365-2826.2006.01485.x

Elevated KiSS-1 expression in the arcuate nucleus prior to the cyclic preovulatory gonadotrophin-releasing hormone/lutenising hormone surge in the ewe suggests a stimulatory role for kisspeptin in oestrogen-positive feedback

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