Elevated KiSS-1 expression in the arcuate nucleus prior to the cyclic preovulatory gonadotrophin-releasing hormone/lutenising hormone surge in the ewe suggests a stimulatory role for kisspeptin in oestrogen-positive feedback

K. M. Estrada, C. M. Clay, S. Pompolo, Jeremy Smith, Iain J. Clarke

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

Kisspeptins are encoded by the gene KiSS-1 and regulate gonadotrophin-releasing hormone (GnRH) and gonadotrophin secretion in various species, including humans. Here, we quantify gene expression of KiSS-1 in the arcuate nucleus (ARC) across the ovine oestrous cycle and demonstrate an increase in the caudal division of the ARC during the preovulatory period. These data strongly suggest that kisspeptins are involved in the generation of the preovulatory GnRH and luteinising hormone surge.

Original languageEnglish
Pages (from-to)806-809
Number of pages4
JournalJournal of Neuroendocrinology
Volume18
Issue number10
DOIs
Publication statusPublished - Oct 2006
Externally publishedYes

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