Elevated circulating osteoprotegerin and renal dysfunction predict 15-year cardiovascular and all-cause mortality: A prospective study of elderly women

Joshua Lewis, Wai Lim, T. Ueland, G. Wong, Kun Zhu, E.M. Lim, J. Bollerslev, Richard Prince

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    ©2015 Lewis et al.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background: Data on the predictive role of estimated glomerular filtration rate (eGFR) and osteoprotegerin (OPG) for cardiovascular (CVD) and all-cause mortality risk have been presented by our group and others. We now present data on the interactions between OPG with stage I to III chronic kidney disease (CKD) for all-cause and CVD mortality. Methods and Results: The setting was a 15-year study of 1,292 women over 70 years of age initially randomized to a 5-year controlled trial of 1.2 g of calcium daily. Serum OPG and creatinine levels with complete mortality records obtained from the Western Australian Data Linkage System were available. Interactions were detected between OPG levels and eGFR for both CVD and all-cause mortality (P <0.05). Compared to participants with eGFR ≥60ml/min/1.73m2 and low OPG, participants with eGFR of 2 and elevated OPG had a 61% and 75% increased risk of all-cause and CVD mortality respectively (multivariate-adjusted HR, 1.61; 95% CI, 1.27-2.05; P <0.001 and HR, 1.75; 95% CI, 1.22-2.55; P = 0.003). This relationship with mortality was independent of decline in renal function (P
    Original languageEnglish
    Article numbere0134266
    Pages (from-to)1-14
    Number of pages14
    JournalPLoS One
    Volume10
    Issue number7
    DOIs
    Publication statusPublished - 29 Jul 2015

    Fingerprint Dive into the research topics of 'Elevated circulating osteoprotegerin and renal dysfunction predict 15-year cardiovascular and all-cause mortality: A prospective study of elderly women'. Together they form a unique fingerprint.

    Cite this