TY - JOUR
T1 - Electrospun Chitosan-graft-PLGA nanofibres with significantly enhanced hydrophilicity and improved mechanical property
AU - Li, A.D.
AU - Sun, Z.
AU - Zhou, M.
AU - Xu, Xiaoxue
AU - Ma, J.Y.
AU - Zheng, W.
AU - Zhou, H.
AU - Li, L.
AU - Zheng, Y.
PY - 2013
Y1 - 2013
N2 - This work reported a novel poly(lactic-co-glycolic acid) (PLGA) composite nanofibres, Chitosan-graft-PLGA (CS-graft-PLGA), produced by the electrospinning technique. CS was grafted onto the PLGA surface via the cross-linking agents reacting with the PLGA with reactive carboxyl groups on its surfaces introduced from the alkali treatment. The CS grafting ratios of the electrospun CS-graft-PLGA nanofibres were about 2.43%, 4.34%, 16.97% and 39.4% after cross-linked for 12. h, 16. h, 20. h and 24. h, respectively. The electrospun CS-graft-PLGA nanofibres were significantly uniform and highly smooth without the occurrence of bead defects, even at high CS grafting ratio. The electrospun CS-graft-PLGA nanofibres not only possessed the improved hydrophilicity and the protein absorption property, but also maintained the good mechanical property. In addition, the CS grafting can be conducive to accelerate degradation rate of PLGA. © 2012 Elsevier B.V.
AB - This work reported a novel poly(lactic-co-glycolic acid) (PLGA) composite nanofibres, Chitosan-graft-PLGA (CS-graft-PLGA), produced by the electrospinning technique. CS was grafted onto the PLGA surface via the cross-linking agents reacting with the PLGA with reactive carboxyl groups on its surfaces introduced from the alkali treatment. The CS grafting ratios of the electrospun CS-graft-PLGA nanofibres were about 2.43%, 4.34%, 16.97% and 39.4% after cross-linked for 12. h, 16. h, 20. h and 24. h, respectively. The electrospun CS-graft-PLGA nanofibres were significantly uniform and highly smooth without the occurrence of bead defects, even at high CS grafting ratio. The electrospun CS-graft-PLGA nanofibres not only possessed the improved hydrophilicity and the protein absorption property, but also maintained the good mechanical property. In addition, the CS grafting can be conducive to accelerate degradation rate of PLGA. © 2012 Elsevier B.V.
U2 - 10.1016/j.colsurfb.2012.09.035
DO - 10.1016/j.colsurfb.2012.09.035
M3 - Article
VL - 102
SP - 674
EP - 681
JO - COLLOIDS AND SURFACES B-BIOINTERFACES
JF - COLLOIDS AND SURFACES B-BIOINTERFACES
SN - 0927-7765
ER -