EGFL7: Master regulator of cancer pathogenesis, angiogenesis and an emerging mediator of bone homeostasis

Guoju Hong, Vincent Kuek, Jiaxi Shi, Lin Zhou, Xiaorui Han, Wei He, Jennifer Tickner, Heng Qiu, Qiushi Wei, Jiake Xu

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Epidermal growth factor-like domain-containing protein 7 (EGFL7), a member of the epidermal growth factor (EGF)-like protein family, is a potent angiogenic factor expressed in many different cell types. EGFL7 plays a vital role in controlling vascular angiogenesis during embryogenesis, organogenesis, and maintaining skeletal homeostasis. It regulates cellular functions by mediating the main signaling pathways (Notch, integrin) and EGF receptor cascades. Accumulating evidence suggests that Egfl7 plays a crucial role in cancer biology by modulating tumor angiogenesis, metastasis, and invasion. Dysregulation of Egfl7 has been frequently found in several types of cancers, such as malignant glioma, colorectal carcinoma, oral and oesophageal cancers, gastric cancer, hepatocellular carcinoma, pancreatic cancer, breast cancer, lung cancer, osteosarcoma, and acute myeloid leukemia. In addition, altered expression of miR-126, a microRNA associated with Egfl7, was found to play an important role in oncogenesis. More recently, our study has shown that EGFL7 is expressed in both the osteoclast and osteoblast lineages and promotes endothelial cell activities via extracellular signal-regulated kinase (ERK), signal transducer and activator of transcription 3 (STAT3), and integrin signaling cascades, indicative of its angiogenic regulation in the bone microenvironment. Thus, understanding the role of EGFL7 may provide novel insights into the development of improved diagnostics and therapeutic treatment for cancers and skeletal pathological disorders, such as ischemic osteonecrosis and bone fracture healing.

Original languageEnglish
Pages (from-to)8526-8537
Number of pages12
JournalJournal of Cellular Physiology
Volume233
Issue number11
DOIs
Publication statusPublished - 1 Nov 2018

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Epidermal Growth Factor
Bone
Homeostasis
Bone and Bones
Integrins
Stomach Neoplasms
Colorectal Neoplasms
Lung Neoplasms
Neoplasms
Proteins
Breast Neoplasms
STAT3 Transcription Factor
Fracture Healing
Osteonecrosis
Organogenesis
Angiogenesis Inducing Agents
Mouth Neoplasms
Osteoblasts
Bone Fractures
Extracellular Signal-Regulated MAP Kinases

Cite this

@article{2e19233901044231800b74c41da96fa0,
title = "EGFL7: Master regulator of cancer pathogenesis, angiogenesis and an emerging mediator of bone homeostasis",
abstract = "Epidermal growth factor-like domain-containing protein 7 (EGFL7), a member of the epidermal growth factor (EGF)-like protein family, is a potent angiogenic factor expressed in many different cell types. EGFL7 plays a vital role in controlling vascular angiogenesis during embryogenesis, organogenesis, and maintaining skeletal homeostasis. It regulates cellular functions by mediating the main signaling pathways (Notch, integrin) and EGF receptor cascades. Accumulating evidence suggests that Egfl7 plays a crucial role in cancer biology by modulating tumor angiogenesis, metastasis, and invasion. Dysregulation of Egfl7 has been frequently found in several types of cancers, such as malignant glioma, colorectal carcinoma, oral and oesophageal cancers, gastric cancer, hepatocellular carcinoma, pancreatic cancer, breast cancer, lung cancer, osteosarcoma, and acute myeloid leukemia. In addition, altered expression of miR-126, a microRNA associated with Egfl7, was found to play an important role in oncogenesis. More recently, our study has shown that EGFL7 is expressed in both the osteoclast and osteoblast lineages and promotes endothelial cell activities via extracellular signal-regulated kinase (ERK), signal transducer and activator of transcription 3 (STAT3), and integrin signaling cascades, indicative of its angiogenic regulation in the bone microenvironment. Thus, understanding the role of EGFL7 may provide novel insights into the development of improved diagnostics and therapeutic treatment for cancers and skeletal pathological disorders, such as ischemic osteonecrosis and bone fracture healing.",
keywords = "angiogenesis, cancer, EGF-like domain-containing protein 7 (EGFL7), epidermal growth factor (EGF)-like, skeletal system",
author = "Guoju Hong and Vincent Kuek and Jiaxi Shi and Lin Zhou and Xiaorui Han and Wei He and Jennifer Tickner and Heng Qiu and Qiushi Wei and Jiake Xu",
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EGFL7 : Master regulator of cancer pathogenesis, angiogenesis and an emerging mediator of bone homeostasis. / Hong, Guoju; Kuek, Vincent; Shi, Jiaxi; Zhou, Lin; Han, Xiaorui; He, Wei; Tickner, Jennifer; Qiu, Heng; Wei, Qiushi; Xu, Jiake.

In: Journal of Cellular Physiology, Vol. 233, No. 11, 01.11.2018, p. 8526-8537.

Research output: Contribution to journalReview article

TY - JOUR

T1 - EGFL7

T2 - Master regulator of cancer pathogenesis, angiogenesis and an emerging mediator of bone homeostasis

AU - Hong, Guoju

AU - Kuek, Vincent

AU - Shi, Jiaxi

AU - Zhou, Lin

AU - Han, Xiaorui

AU - He, Wei

AU - Tickner, Jennifer

AU - Qiu, Heng

AU - Wei, Qiushi

AU - Xu, Jiake

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Epidermal growth factor-like domain-containing protein 7 (EGFL7), a member of the epidermal growth factor (EGF)-like protein family, is a potent angiogenic factor expressed in many different cell types. EGFL7 plays a vital role in controlling vascular angiogenesis during embryogenesis, organogenesis, and maintaining skeletal homeostasis. It regulates cellular functions by mediating the main signaling pathways (Notch, integrin) and EGF receptor cascades. Accumulating evidence suggests that Egfl7 plays a crucial role in cancer biology by modulating tumor angiogenesis, metastasis, and invasion. Dysregulation of Egfl7 has been frequently found in several types of cancers, such as malignant glioma, colorectal carcinoma, oral and oesophageal cancers, gastric cancer, hepatocellular carcinoma, pancreatic cancer, breast cancer, lung cancer, osteosarcoma, and acute myeloid leukemia. In addition, altered expression of miR-126, a microRNA associated with Egfl7, was found to play an important role in oncogenesis. More recently, our study has shown that EGFL7 is expressed in both the osteoclast and osteoblast lineages and promotes endothelial cell activities via extracellular signal-regulated kinase (ERK), signal transducer and activator of transcription 3 (STAT3), and integrin signaling cascades, indicative of its angiogenic regulation in the bone microenvironment. Thus, understanding the role of EGFL7 may provide novel insights into the development of improved diagnostics and therapeutic treatment for cancers and skeletal pathological disorders, such as ischemic osteonecrosis and bone fracture healing.

AB - Epidermal growth factor-like domain-containing protein 7 (EGFL7), a member of the epidermal growth factor (EGF)-like protein family, is a potent angiogenic factor expressed in many different cell types. EGFL7 plays a vital role in controlling vascular angiogenesis during embryogenesis, organogenesis, and maintaining skeletal homeostasis. It regulates cellular functions by mediating the main signaling pathways (Notch, integrin) and EGF receptor cascades. Accumulating evidence suggests that Egfl7 plays a crucial role in cancer biology by modulating tumor angiogenesis, metastasis, and invasion. Dysregulation of Egfl7 has been frequently found in several types of cancers, such as malignant glioma, colorectal carcinoma, oral and oesophageal cancers, gastric cancer, hepatocellular carcinoma, pancreatic cancer, breast cancer, lung cancer, osteosarcoma, and acute myeloid leukemia. In addition, altered expression of miR-126, a microRNA associated with Egfl7, was found to play an important role in oncogenesis. More recently, our study has shown that EGFL7 is expressed in both the osteoclast and osteoblast lineages and promotes endothelial cell activities via extracellular signal-regulated kinase (ERK), signal transducer and activator of transcription 3 (STAT3), and integrin signaling cascades, indicative of its angiogenic regulation in the bone microenvironment. Thus, understanding the role of EGFL7 may provide novel insights into the development of improved diagnostics and therapeutic treatment for cancers and skeletal pathological disorders, such as ischemic osteonecrosis and bone fracture healing.

KW - angiogenesis

KW - cancer

KW - EGF-like domain-containing protein 7 (EGFL7)

KW - epidermal growth factor (EGF)-like

KW - skeletal system

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U2 - 10.1002/jcp.26792

DO - 10.1002/jcp.26792

M3 - Review article

VL - 233

SP - 8526

EP - 8537

JO - Journal Cellular Physiology

JF - Journal Cellular Physiology

SN - 0021-9541

IS - 11

ER -