Efficacy of alternative medicaments for pulp treatment in primary teeth in the short-term: meta-analysis

Joon Soo Park; Bosky Jasani; Jilen Patel; Robert Anthonappa; Nigel King

doi:10.1016/j.jebdp.2019.01.005

Efficacy of alternative medicaments for pulp treatment in primary teeth in the short-term: meta-analysis

Joon Soo Park, Bosky Jasani, Jilen Patel, Robert Anthonappa, Nigel King

Dental School

Research output: Contribution to journal › Review article

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Abstract

Objective

This systematic review and meta-analysis aimed to evaluate the overall, clinical, and radiographical success rates of alternative pulpotomy medicaments in primary teeth.
Methods

A systematic search of five databases was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Prospective clinical trials using alternative pulpotomy medicaments in children were included. The outcome measures were overall, clinical, and radiographic success, expressed in percentages and converted to odds ratios. Fifteen articles were included in the meta-analysis.
Results

Combined odds ratios for overall, clinical, and radiographic success was 0.55 (95% confidence interval [CI]: 0.12-2.41; P = .42; I2 = 76%), 1.03 (95% CI: 0.57-1.86; P = .92; I2 = 0%), and 0.84 (95% CI: 0.54-1.47; P = .66; I2 = 34%), respectively. The results suggest an inconclusive outcome in the success rate of alternative medicaments.
Conclusions

There is insufficient evidence to support the efficacy of alternative pulpotomy medicaments for use in primary teeth. Further robust studies are required before such alternative medicaments should be used in clinical practice.

Original language	English
Article number	101309
Journal	Journal of Evidence-Based Dental Practice
Volume	19
Issue number	4
DOIs	https://doi.org/10.1016/j.jebdp.2019.01.005
Publication status	Published - Dec 2019

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10.1016/j.jebdp.2019.01.005

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Park et al 2019 Efficacy of alternative medicaments for pulp treatment
Accepted author manuscript, 3.7 MB
Licence: CC BY-NC-ND
Embargo ends: 13/12/20

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Park, J. S., Jasani, B., Patel, J., Anthonappa, R., & King, N. (2019). Efficacy of alternative medicaments for pulp treatment in primary teeth in the short-term: meta-analysis. Journal of Evidence-Based Dental Practice, 19(4), [101309]. https://doi.org/10.1016/j.jebdp.2019.01.005

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abstract = "ObjectiveThis systematic review and meta-analysis aimed to evaluate the overall, clinical, and radiographical success rates of alternative pulpotomy medicaments in primary teeth.MethodsA systematic search of five databases was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Prospective clinical trials using alternative pulpotomy medicaments in children were included. The outcome measures were overall, clinical, and radiographic success, expressed in percentages and converted to odds ratios. Fifteen articles were included in the meta-analysis.ResultsCombined odds ratios for overall, clinical, and radiographic success was 0.55 (95% confidence interval [CI]: 0.12-2.41; P = .42; I2 = 76%), 1.03 (95% CI: 0.57-1.86; P = .92; I2 = 0%), and 0.84 (95% CI: 0.54-1.47; P = .66; I2 = 34%), respectively. The results suggest an inconclusive outcome in the success rate of alternative medicaments.ConclusionsThere is insufficient evidence to support the efficacy of alternative pulpotomy medicaments for use in primary teeth. Further robust studies are required before such alternative medicaments should be used in clinical practice.",

author = "Park, {Joon Soo} and Bosky Jasani and Jilen Patel and Robert Anthonappa and Nigel King",

year = "2019",

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doi = "10.1016/j.jebdp.2019.01.005",

language = "English",

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T1 - Efficacy of alternative medicaments for pulp treatment in primary teeth in the short-term: meta-analysis

AU - Park, Joon Soo

AU - Jasani, Bosky

AU - Patel, Jilen

AU - Anthonappa, Robert

AU - King, Nigel

PY - 2019/12

Y1 - 2019/12

N2 - ObjectiveThis systematic review and meta-analysis aimed to evaluate the overall, clinical, and radiographical success rates of alternative pulpotomy medicaments in primary teeth.MethodsA systematic search of five databases was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Prospective clinical trials using alternative pulpotomy medicaments in children were included. The outcome measures were overall, clinical, and radiographic success, expressed in percentages and converted to odds ratios. Fifteen articles were included in the meta-analysis.ResultsCombined odds ratios for overall, clinical, and radiographic success was 0.55 (95% confidence interval [CI]: 0.12-2.41; P = .42; I2 = 76%), 1.03 (95% CI: 0.57-1.86; P = .92; I2 = 0%), and 0.84 (95% CI: 0.54-1.47; P = .66; I2 = 34%), respectively. The results suggest an inconclusive outcome in the success rate of alternative medicaments.ConclusionsThere is insufficient evidence to support the efficacy of alternative pulpotomy medicaments for use in primary teeth. Further robust studies are required before such alternative medicaments should be used in clinical practice.

AB - ObjectiveThis systematic review and meta-analysis aimed to evaluate the overall, clinical, and radiographical success rates of alternative pulpotomy medicaments in primary teeth.MethodsA systematic search of five databases was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Prospective clinical trials using alternative pulpotomy medicaments in children were included. The outcome measures were overall, clinical, and radiographic success, expressed in percentages and converted to odds ratios. Fifteen articles were included in the meta-analysis.ResultsCombined odds ratios for overall, clinical, and radiographic success was 0.55 (95% confidence interval [CI]: 0.12-2.41; P = .42; I2 = 76%), 1.03 (95% CI: 0.57-1.86; P = .92; I2 = 0%), and 0.84 (95% CI: 0.54-1.47; P = .66; I2 = 34%), respectively. The results suggest an inconclusive outcome in the success rate of alternative medicaments.ConclusionsThere is insufficient evidence to support the efficacy of alternative pulpotomy medicaments for use in primary teeth. Further robust studies are required before such alternative medicaments should be used in clinical practice.

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DO - 10.1016/j.jebdp.2019.01.005

M3 - Review article

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VL - 19

JO - Journal of Evidence-Based Dental Practice

JF - Journal of Evidence-Based Dental Practice

SN - 1532-3382

IS - 4

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